Research Progress on the Regulation of LncRNA in the Development of Mammalian Hair Follicle

doi:10.13560/j.cnki.biotech.bull.1985.2019-0187

Abstract

Abstract: Long non-coding RNA is a kind of eukaryotic transcripts that are more than 200nt in length and do not encode proteins by themselves. It is a key regulator of protein-coding gene expression,which is widely distributed in the genome of animals and plants,regulating gene expression at the transcriptional and post-transcriptional levels,and as an important regulator participates biological processes in life development cycles,cell differentiation and diseases. Although,several lncRNAs relevant to skin biology have been reported,the detailed functions and mechanisms of lncRNAs in hair follicle development and hair fibers are rare. The combination of new generation sequencing technology and microarray technology provides more accurate and rapid way for the identification of lncRNAs. It has been showed that some lncRNAs affect the cells proliferation and differentiation of skin hair follicle and the formation of dermal papilla,and their target genes involve in the regulation of in the periodic growth of hair follicles. In this review,the regulatory effect of lncRNA on hair follicle growth and development is summarized in order to provide a theoretical basis for the further study of the role and regulatory mechanism of lncRNA related to mammalian hair follicle growth and development.

Key words: lncRNA, skin, hair follicle, regulatory mechanism

CHANG Yong-fang, BAO Peng-jia, CHU Min, WU Xiao-yun, LIANG Chun-nian, YAN Ping. Research Progress on the Regulation of LncRNA in the Development of Mammalian Hair Follicle[J]. Biotechnology Bulletin, 2019, 35(8): 205-212.

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