Research Progress on Innate Immunity-Related Coding Genes in the Regulation of Cow Mastitis

doi:10.13560/j.cnki.biotech.bull.1985.2020-0429

Abstract

Abstract:

Mastitis is one of the most common diseases in dairy cattle,especially in high-yield individuals,which has caused huge economic losses to the modern dairy industry. In order to clarify the molecular mechanism of dairy cow mastitis and carry out anti-mastitis molecular breeding,scholars have carried out a lot of research works on the regulatory mechanism of innate immunity on dairy cow mastitis. It is found that coding genes such as cell pattern recognition receptors,signal pathway,inflammatory cytokines,inflammatory chemokines,host defensins and antimicrobial peptides play an important role in breast innate immune response. This article summarizes the research progress on classification,expression pattern,molecular regulation mechanism of innate immunity-related coding genes as well as the mining of mastitis-related SNPs in bovine mammary gland,which will provide reference for systematic understanding and further study of the molecular regulation mechanism of dairy cow mastitis.

Key words: dairy cows, mastitis, innate immunity, signal pathway, TLRs

HU Qi-chao, LUORENG Zhuo-ma, WEI Da-wei, YANG Jian, JIA Li, WANG Xing-ping, MA Yun. Research Progress on Innate Immunity-Related Coding Genes in the Regulation of Cow Mastitis[J]. Biotechnology Bulletin, 2020, 36(12): 239-246.

Figures/Tables 1

References 58

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