Research Progress on Anti-biofilm Peptides

doi:10.13560/j.cnki.biotech.bull.1985.2020-0577

Abstract

Abstract:

The increase in bacterial resistance caused by bacterial biofilms has received widespread attention. Anti-biofilm peptides are a class of antimicrobial peptides with unique advantages in inhibiting and killing bacterial biofilms,and are expected to become ideal new antibacterial drugs against bacterial biofilms. This paper mainly reviews how anti-biofilm peptides interact with biofilm components,the intervention and regulation of anti-biofilm peptides on biofilm formation,the current issues of anti-biofilm peptides and solutions,and the future applications of anti-biofilm peptides.

Key words: bacterial biofilm, anti-biofilm peptide, interaction

ZHANG Yang, CHENG Peng, LI Xiao-fen, CHEN Hong-wei. Research Progress on Anti-biofilm Peptides[J]. Biotechnology Bulletin, 2021, 37(2): 216-223.

Figures/Tables 1

References 51

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名称	影响阶段	作用的菌株	来源	作用方式	文献
LL-37 LL-37衍生物	黏附阶段形成阶段成熟阶段	大肠杆菌铜绿假单胞菌鲍曼不动杆菌	人	杀灭浮游菌;抑制生物膜形成;某些衍生物（如KS-30）能破坏生物膜结构	[19]
SPLUNC1-α4M1	形成阶段	金黄色葡萄球菌	人	抑制生物膜形成	[35]
RN3（5-17P22-36）	成熟阶段	铜绿假单胞菌	人源衍生物	清除成熟生物膜;杀灭生物膜细菌	[10]
PEP-NJSM	黏附阶段形成阶段成熟阶段	表皮葡萄球菌	人病毒蛋白组	减少原始细菌黏附;抑制生物膜细菌活性;提高生物膜细菌死亡率	[43]
IDR-1018	形成阶段成熟阶段	粪肠球菌金黄色葡萄球菌铜绿假单胞菌鲍曼不动杆菌	牛	清除成熟生物膜;提高抗生素或者抗微生物肽的抗生物膜能力	[44]
BMAP-28	黏附阶段	白色念珠菌	牛	杀灭浮游细菌	[25]
CRAMP	成熟阶段	铜绿假单胞菌	鼠	清除成熟生物膜	[21]
P318	形成阶段	白色念珠菌大肠杆菌铜绿假单胞菌	鼠源衍生物	抑制生物膜细菌活性	[20]
Cath-2	黏附阶段成熟阶段	表皮葡萄球菌	鸡	减少原始细菌黏附;杀灭生物膜细菌	[45]
MC1	形成阶段	铜绿假单胞菌	蛙源衍生物	下调Pel、AlgD和Psl基因抑制多糖合成	[26]
PT13	形成阶段	金黄色葡萄球菌	胡杨	抑制细胞粘附和粘附蛋白编码基因表达	[7]
CLP	形成阶段成熟阶段	表皮葡萄球菌	淀粉芽孢杆菌	降低EPS组分（多糖、蛋白质、eDNA）;破坏EPS结构	[5]
Nisin	形成阶段	铜绿假单胞菌	乳酸链球菌	降低生物膜多糖、eDNA含量;减少原始细菌黏附	[15]
Pep19-2.5	形成阶段	变异链球菌	人工合成	抑制细菌生长活性	[46]
P5	形成阶段	铜绿假单胞菌	人工合成	破坏生物膜结构;杀灭生物膜细菌	[42]
ZY4	成熟阶段	铜绿假单胞菌	人工合成	清除成熟生物膜和杀灭持留菌	[22]
KP	形成阶段成熟阶段	白色念珠菌	人工合成	破坏生物膜结构;抑制生物膜形成相关基因表达	[23]
LIVRHK;LIVRRK	形成阶段	铜绿假单胞菌	人工合成	抑制了Lasl/R和Rhl/R的表达;抑制毒力因子产生	[28]
WLBU2	形成阶段	铜绿假单胞菌	人工合成	抑制生物膜形成	[41]

名称	影响阶段	作用的菌株	来源	作用方式	文献
LL-37 LL-37衍生物	黏附阶段形成阶段成熟阶段	大肠杆菌铜绿假单胞菌鲍曼不动杆菌	人	杀灭浮游菌;抑制生物膜形成;某些衍生物（如KS-30）能破坏生物膜结构	[19]
SPLUNC1-α4M1	形成阶段	金黄色葡萄球菌	人	抑制生物膜形成	[35]
RN3（5-17P22-36）	成熟阶段	铜绿假单胞菌	人源衍生物	清除成熟生物膜;杀灭生物膜细菌	[10]
PEP-NJSM	黏附阶段形成阶段成熟阶段	表皮葡萄球菌	人病毒蛋白组	减少原始细菌黏附;抑制生物膜细菌活性;提高生物膜细菌死亡率	[43]
IDR-1018	形成阶段成熟阶段	粪肠球菌金黄色葡萄球菌铜绿假单胞菌鲍曼不动杆菌	牛	清除成熟生物膜;提高抗生素或者抗微生物肽的抗生物膜能力	[44]
BMAP-28	黏附阶段	白色念珠菌	牛	杀灭浮游细菌	[25]
CRAMP	成熟阶段	铜绿假单胞菌	鼠	清除成熟生物膜	[21]
P318	形成阶段	白色念珠菌大肠杆菌铜绿假单胞菌	鼠源衍生物	抑制生物膜细菌活性	[20]
Cath-2	黏附阶段成熟阶段	表皮葡萄球菌	鸡	减少原始细菌黏附;杀灭生物膜细菌	[45]
MC1	形成阶段	铜绿假单胞菌	蛙源衍生物	下调Pel、AlgD和Psl基因抑制多糖合成	[26]
PT13	形成阶段	金黄色葡萄球菌	胡杨	抑制细胞粘附和粘附蛋白编码基因表达	[7]
CLP	形成阶段成熟阶段	表皮葡萄球菌	淀粉芽孢杆菌	降低EPS组分（多糖、蛋白质、eDNA）;破坏EPS结构	[5]
Nisin	形成阶段	铜绿假单胞菌	乳酸链球菌	降低生物膜多糖、eDNA含量;减少原始细菌黏附	[15]
Pep19-2.5	形成阶段	变异链球菌	人工合成	抑制细菌生长活性	[46]
P5	形成阶段	铜绿假单胞菌	人工合成	破坏生物膜结构;杀灭生物膜细菌	[42]
ZY4	成熟阶段	铜绿假单胞菌	人工合成	清除成熟生物膜和杀灭持留菌	[22]
KP	形成阶段成熟阶段	白色念珠菌	人工合成	破坏生物膜结构;抑制生物膜形成相关基因表达	[23]
LIVRHK;LIVRRK	形成阶段	铜绿假单胞菌	人工合成	抑制了Lasl/R和Rhl/R的表达;抑制毒力因子产生	[28]
WLBU2	形成阶段	铜绿假单胞菌	人工合成	抑制生物膜形成	[41]