Biotechnology Bulletin ›› 2023, Vol. 39 ›› Issue (9): 12-26.doi: 10.13560/j.cnki.biotech.bull.1985.2023-0188

Previous Articles     Next Articles

Application of Chemical Proteomics in Identifying the Molecular Targets of Natural Products

ZHOU Lu-qi1(), CUI Ting-ru2, HAO Nan1, ZHAO Yu-wei1, ZHAO Bin1(), LIU Ying-chao1()   

  1. 1. Hebei Agricultural University, College of Plant Protection, Hebei Key Laboratory of Plant Physiology and Molecular Pathology, Baoding 071000
    2. Baoding Meteorological Bureau, Baoding 071000
  • Received:2023-03-03 Online:2023-09-26 Published:2023-10-24
  • Contact: ZHAO Bin, LIU Ying-chao E-mail:luqizhou_hbnd@126.com;bdzhaobin@126.com;liuyingchao@hebau.edu.cn

Abstract:

The development and utilization of new green pesticides are conducive to the sustainable development of agriculture. Studying active leading discovery and action mechanisms based on natural products is essential for creating new pesticides. However, its target and action mechanism are difficult to determine, which hinders its development in new drug research and development. Therefore, discovering compound new targets is an important and arduous task for creating new pesticides. As a new technology in the post-genomic era, chemical proteomics has become one of the essential means of drug targeting. This paper reviewed the discovery methods and typical cases of molecular targets of chemical compounds based on proteomics and introduced main principles, applications, advantages and limitations of these technologies, aiming to provide references for the research of natural product targets and new pesticide creation by explaining the progress of the latest methods of discovering drug action targets based on chemical proteomics.

Key words: chemical proteomics, target identification, chemical probe, non-chemical probe, natural products