Investigation of Autophagy Induced by Amino Acid Deprivation and the Regulatory Mechanisms of miRNA in Autophagy

doi:10.13560/j.cnki.biotech.bull.1985.2016.09.006

Abstract

Abstract: Amino acid is a kind of indispensable nutriment and basic material for life activities,and it is critical for animal to maintain physiological function. Autophagy is a pathway to accomplish metabolism and regenerate some organelles by the turnover and recycling of intracellular macromolecules and damaged organelles. The studies confirmed that amino acid deprivation induced the cell autophagy through the mTORC1 signal pathway. However,the molecular mechanism and level of autophagy differ significantly between total and individual amino acid,moreover,the molecular regulatory mechanism is still unclear,and further revealing is necessary. miRNA is non-coding nucleotide with 18-24 nt involving in cell proliferation,differentiation,autophagy,and apoptosis. Recent researches show that miRNA plays an important role in regulating autophagy induced by amino acid deprivation. This paper reviewed the regulatory mechanisms of autophagy by different amino acid deprivation and the key effects of miRNA on autophagy,aim to provide new approach to treat related metablic disease.

Key words: amino acid deprivation, miRNA, autophagy, mTORC1 signal pathway

WANG Qi, QI Ren-li, WANG Jing, HUANG Jin-xiu. Investigation of Autophagy Induced by Amino Acid Deprivation and the Regulatory Mechanisms of miRNA in Autophagy[J]. Biotechnology Bulletin, 2016, 32(9): 38-43.

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