Biotechnology Bulletin ›› 2022, Vol. 38 ›› Issue (12): 1-10.doi: 10.13560/j.cnki.biotech.bull.1985.2022-0014
LI Xiao-fan1,2(), GENG Dan-dan1,2, BI Yu-lin2, JIANG Yong2, WANG Zhi-xiu2, CHANG Guo-bin1,2, CHEN Guo-hong1,2, BAI Hao1()
Received:
2022-01-05
Online:
2022-12-26
Published:
2022-12-29
Contact:
BAI Hao
E-mail:ylcccoco@126.com;bhowen1027@yzu.edu.cn
LI Xiao-fan, GENG Dan-dan, BI Yu-lin, JIANG Yong, WANG Zhi-xiu, CHANG Guo-bin, CHEN Guo-hong, BAI Hao. Research Progress in Unconventional miRNA Functions[J]. Biotechnology Bulletin, 2022, 38(12): 1-10.
Fig. 1 Unconventional miRNA functions ①:pri-miRNAs coding for peptides miPEPs;②:miRNAs interacting with non-AGO proteins;③:miRNAs as signals molecules activating TLR receptors;④:miRNAs upregulating protein expression;⑤:miRNAs regulating the gene mRNA related to mitochondria in target;⑥:miRNAs directly regulating gene transcription
作用机制Functions | 物种Species | 性状Traits | 相关miRNAR Related miRNAs | 参考文献Reference |
---|---|---|---|---|
miRNA前体pri-miRNA编码调节肽miPEPs | 植物 | 根系发育 | pri-miR176、pri-miR165a | [ |
pri-mir171d | [ | |||
pri-mir858a | [ | |||
植物 | 叶片发育 | mir-165a | [ | |
植物 | 大豆根瘤结瘤 | mir-172c | [ | |
人类 | 前列腺癌 | miR-200a、miR-200b | [ | |
人类 | 类银屑病与多发性硬化症(EAE) | mir-155 | [ | |
miRNA与多种功能蛋白相结合 | 人类 | 饥饿应激反应 | mir-122 | [ |
人类 | 慢性骨髓性白血病 | mir-328 | [ | |
人类 | 癌细胞发育调节 | mir-346、mir-138、pri-let-7 | [ | |
[ | ||||
动物 | 哺乳动物胚胎发育 | let-7 | [ | |
miRNA作为信号分子直接激活TLR受体蛋白 | 小鼠 | 阿尔茨海默病 | let-7 | [ |
小鼠 | 中枢神经系统疾病 | mir-20a-5p、mir-148b-3p | [ | |
miRNA上调蛋白表达水平 | 人类 | 丙型肝炎病毒(HCV) | mir-122 | [ |
人类 | 巨噬细胞调节 | mir-125b | [ | |
人类 | 宫颈癌 | mir-346 | [ | |
人类 | 小儿癌症 | mir-483 | [ | |
动物 | 肠道菌群调节 | gga-miR-222a | [ | |
植物 | 干旱胁迫 | mir-156 | [ | |
miRNA靶向调控线粒体相关基因mRNA | 人类 | 骨骼肌线粒体调节 | pre-mir-302a、pre-let-7b、mir-365 | [ |
大鼠 | 心脏线粒体调节 | mir-181c | [ | |
人类 | 肿瘤细胞代谢和化学耐药性 | mir-2392 | [ | |
小鼠 | 心肌线粒体调节 | mir-1 | [ | |
人类 | 神经发育 | mir-338 | [ | |
F:miRNA直接调控基因转录过程 | 小鼠 | 肿瘤生长调节 | mir-744、mir-1186 | [ |
小鼠 | 细胞凋亡调节 | mir-709 | [ | |
人类 | 肿瘤生长调节 | miR-24、miR-16a-1 | [ |
Table 1 Research progresses in unconventional miRNA functions
作用机制Functions | 物种Species | 性状Traits | 相关miRNAR Related miRNAs | 参考文献Reference |
---|---|---|---|---|
miRNA前体pri-miRNA编码调节肽miPEPs | 植物 | 根系发育 | pri-miR176、pri-miR165a | [ |
pri-mir171d | [ | |||
pri-mir858a | [ | |||
植物 | 叶片发育 | mir-165a | [ | |
植物 | 大豆根瘤结瘤 | mir-172c | [ | |
人类 | 前列腺癌 | miR-200a、miR-200b | [ | |
人类 | 类银屑病与多发性硬化症(EAE) | mir-155 | [ | |
miRNA与多种功能蛋白相结合 | 人类 | 饥饿应激反应 | mir-122 | [ |
人类 | 慢性骨髓性白血病 | mir-328 | [ | |
人类 | 癌细胞发育调节 | mir-346、mir-138、pri-let-7 | [ | |
[ | ||||
动物 | 哺乳动物胚胎发育 | let-7 | [ | |
miRNA作为信号分子直接激活TLR受体蛋白 | 小鼠 | 阿尔茨海默病 | let-7 | [ |
小鼠 | 中枢神经系统疾病 | mir-20a-5p、mir-148b-3p | [ | |
miRNA上调蛋白表达水平 | 人类 | 丙型肝炎病毒(HCV) | mir-122 | [ |
人类 | 巨噬细胞调节 | mir-125b | [ | |
人类 | 宫颈癌 | mir-346 | [ | |
人类 | 小儿癌症 | mir-483 | [ | |
动物 | 肠道菌群调节 | gga-miR-222a | [ | |
植物 | 干旱胁迫 | mir-156 | [ | |
miRNA靶向调控线粒体相关基因mRNA | 人类 | 骨骼肌线粒体调节 | pre-mir-302a、pre-let-7b、mir-365 | [ |
大鼠 | 心脏线粒体调节 | mir-181c | [ | |
人类 | 肿瘤细胞代谢和化学耐药性 | mir-2392 | [ | |
小鼠 | 心肌线粒体调节 | mir-1 | [ | |
人类 | 神经发育 | mir-338 | [ | |
F:miRNA直接调控基因转录过程 | 小鼠 | 肿瘤生长调节 | mir-744、mir-1186 | [ |
小鼠 | 细胞凋亡调节 | mir-709 | [ | |
人类 | 肿瘤生长调节 | miR-24、miR-16a-1 | [ |
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