Research Progress on Histone Demethylase JMJD3

doi:10.13560/j.cnki.biotech.bull.1985.2017-0148

Abstract

Abstract:

Histone methylation state is dynamically regulated by different groups of histone methyltransferases and demethylases. H3K27me2/3 is controlled by the polycomb group proteins（such as methyltransferase EZH2）,and its demethylation can activate gene expression. At present,two H3K27me3 demethylation enzymes,JMJD3 and UTX,have been identified. Moreover,a large number of studies have found that JMJD3 may promote cell differentiation and aging,and involve in the regulation of the occurrence and development of tumor. Here we summarize the roles and regulation mechanisms of JMJD3 in embryonic development as well as the occurrence and development of tumor,and the broad prospects in tumor diagnosis and treatment,for laying a theoretical basis for the future research work.

Key words: JMJD3, H3K27me3, embryonic development, cell aging, tumorigenesis

HU Shan,HAN Cong,HU Jian-hong,ZHU Hai-jing. Research Progress on Histone Demethylase JMJD3[J]. Biotechnology Bulletin, 2017, 33(9): 64-72.

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