Research Advances on Type I Interferons Used for Understanding Etiology of Canine Diseases and Treatment of Them

doi:10.13560/j.cnki.biotech.bull.1985.2018-0851

Abstract

Abstract: Type I interferons（IFNs）are a group of cytokines with immunological activity. Type I IFNs can function as antiviral role,inhibit cell proliferation,and regulate immunity and anti-tumor effect by the activation and regulation of adaptive and innate immune responses. To date,type I IFNs are mainly used for the therapy of human renal cancer,melanoma and chronic hepatitis B and so on. Some members of type I IFNs have been approved for the treatment of canine parvovirus,feline leukemia virus and feline immunodeficiency virus infections. However,type I IFNs have still not been used for the treatment of canine diseases. This paper reviews the latest advances on the immunologic competence of type I IFNs and IFNs-activated down-stream immune signal pathways,aiming to offer valuable references for researchers in canine diseases.

Key words: interferon, cytokine, canine diseases, treatment

HU Wen, FENG Xun, ZHANG Bao-bao, YAN Zhi-wei, XU Yu-sheng, LIU Yong-sheng. Research Advances on Type I Interferons Used for Understanding Etiology of Canine Diseases and Treatment of Them[J]. Biotechnology Bulletin, 2019, 35(11): 195-200.

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