Biotechnology Bulletin ›› 2022, Vol. 38 ›› Issue (9): 59-71.doi: 10.13560/j.cnki.biotech.bull.1985.2022-0854

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Research Progress in Heteroresistance of Escherichia coli

ZHAO Yan-kun1(), LIU Hui-min2, MENG Lu2, WANG Cheng1, WANG Jia-qi2, ZHENG Nan2()   

  1. 1. Institute of Quality Standards & Testing Technology for Agro-Products,Xinjiang Academy of Agricultural Sciences,Ministry of Agriculture and Rural Affairs-Laboratory of Quality and Safety Risk Assessment for Agro-Products,Key laboratory of Agro-Products quality and safety of Xinjiang,Urumqi 830091
    2. Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193
  • Received:2022-07-10 Online:2022-09-26 Published:2022-10-11
  • Contact: ZHENG Nan E-mail:yankunzhao90@163.com;zhengnan@caas.cn

Abstract:

Escherichia coli is a commonly pathogen in humans and animals,which has developed resistance to a variety of antibiotics. Due to the increasing selection pressure of antibiotics,the E. coli strains are more adaptable and pathogenic,the spread of antimicrobial resistance is faster,and the colonization rate is higher,that poses great challenges to epidemiology and clinical treatment. In recent years,researches related to heteroresistance(HR)of E. coli have been reported. HR refers to the fact that the homologous subpopulations in bacteria show different susceptibility to a certain antibiotic,which is the intermediate stage of sensitive bacteria evolving into drug-resistant bacteria. Different from full resistance,it is difficult for HR to be detected clinically in time,which often leads to the failure of clinical therapy. Therefore,in order to effectively prevent and control E. coli infection and the evolution of antimicrobial resistance,it is particularly important to deeply analyze the epidemiological characteristics and possible mechanisms of E. coli's HR. This paper sorts the studies on HR,and reviews the phenotypic characteristics,detection methods and possible mechanisms of HR. It is aimed to strengthen the understanding and research on the HR of E.coli,and to provide a comprehensive understanding of E. coli antimicrobial resistance process and mechanism,optimizing antibiotics use strategies,and slowing down the emergence of resistant strains.

Key words: Escherichia coli, antibiotics, heteroresistance, mechanism