Research Progress on Contamination Control of Fluoroquinolone Antibiotics and Drug Resistance Genes

doi:10.13560/j.cnki.biotech.bull.1985.2022-0497

Abstract

Abstract:

Fluoroquinolone antibiotics belong to quinolone antibiotics,is a kind of common antibiotics for human and livestock. In recent years,it has been widely used in human and animal husbandry,aquaculture and other aquaculture fields. However,its massive use has caused continuous residue and accumulation in the environment,posing a great threat to the natural environment and human health. Existing studies show that microbial degradation is one of the effective methods to remove the residual contamination of fluoroquinolone antibiotics. This paper summarized and introduced the practical application of fluoroquinolone antibiotics in microbial degradation of single strain and mixed bacteria,microbial degradation enzymes,degradation pathways and fluoroquinolone antibiotics in recent years,and analyzed the existing issues in the study of fluoroquinolone antibiotics microbial degradation. In addition,the paper also discussed the research focus of fluoroquinolone antibiotics microbial degradation in the future,aiming to provide reference for the follow-up research.

Key words: fluoroquinolone antibiotics, degradation bacteria, degradation enzyme, degradation pathway

LI Liu, MU Ying-chun, LIU Lu, ZHANG Hong-yu, XU Jin-hua, YANG Zhen, QIAO Lu, SONG Jin-long. Research Progress on Contamination Control of Fluoroquinolone Antibiotics and Drug Resistance Genes[J]. Biotechnology Bulletin, 2022, 38(9): 84-95.

Figures/Tables 3

References 61

[1]	张灵巧. 喹诺酮类药物的作用机制及不良反应分析[J]. 健康之路, 2017, 16(10):114-115.
	Zhang LQ. Analysis of the mechanism of action and adverse reactions of quinolones[J]. Heal Way, 2017, 16(10):114-115.
[2]	陈默. 氟喹诺酮类抗生素在鲤鱼体内的富集与代谢[D]. 大连: 大连理工大学, 2019.
	Chen M. Bioconcentration and metabolism of fluoroquinolones(FQs)in common carp(Cyprinus carpio)[D]. Dalian: Dalian University of Technology, 2019.
[3]	贾晨, 高峰, 吕芳, 等. 底泥中氟喹诺酮类抗生素残留检测方法的研究进展[J]. 质量安全与检验检测, 2021, 31(5):56-58.
	Jia C, Gao F, Lyu F, et al. Research advances on detection of fluoroquinolones residues in sediment[J]. Qual Saf Insp Test, 2021, 31(5):56-58.
[4]	张君, 封丽, 田隽, 等. 氟喹诺酮类在环境中的分布及去除研究进展[J]. 环境科学与技术, 2019, 42(S1):77-84.
	Zhang J, Feng L, Tian J, et al. Distribution characteristics in the environment and research progress treatment technology of fluoroquinolone antibiotics[J]. Environ Sci Technol, 2019, 42(S1):77-84.
[5]	沙乃庆, 李艳红. 氟喹诺酮类抗生素水污染现状及去除技术研究进展[J]. 工业水处理, 2021, 41(5):22-28.
	Sha NQ, Li YH. Current situation of water pollution and research progress treatment technology of fluoroquinolone antibiotics[J]. Ind Water Treat, 2021, 41(5):22-28.
[6]	剧泽佳, 赵鑫宇, 陈慧, 等. 石家庄市水环境中喹诺酮类抗生素的空间分布特征与环境风险评估[J]. 环境科学学报, 2021, 41(12):4919-4931.
	Ju ZJ, Zhao XY, Chen H, et al. The characteristics of spatial distribution and environmental risk assessment for Quinolones antibiotics in the aquatic environment of Shijiazhuang City[J]. Acta Sci Circumstantiae, 2021, 41(12):4919-4931.
[7]	蓝贤瑾, 刘益仁, 吕真真, 等. 氟喹诺酮类抗生素在我国农田土壤中残留及其风险研究进展[J]. 江西农业学报, 2019, 31(9):108-115.
	Lan XJ, Liu YR, Lv ZZ, et al. Research advance in residues and ecological risks of fluoroquinolone antibiotics in agricultural soil in China[J]. Acta Agric Jiangxi, 2019, 31(9):108-115.
[8]	徐志华, 孟勇, 杨洪生, 等. 江苏典型养殖区斑点叉尾鮰中多种药物的残留与膳食暴露评估[J]. 中国渔业质量与标准, 2021, 11(5):1-8.
	Xu ZH, Meng Y, Yang HS, et al. Residues and dietary exposure assessment of multiple drugs in Ictalurus punctatus in typical aquaculture areas of Jiangsu[J]. Chin Fish Qual Stand, 2021, 11(5):1-8.
[9]	Amorim CL, Moreira IS, Maia AS, et al. Biodegradation of ofloxacin, norfloxacin, and ciprofloxacin as single and mixed substrates by Labrys portucalensis F₁₁[J]. Appl Microbiol Biotechnol, 2014, 98(7):3181-3190. doi: 10.1007/s00253-013-5333-8 URL
[10]	喻娇. 环丙沙星(CIP)降解菌群驯化及降解特性初步研究[D]. 广州: 暨南大学, 2017.
	Yu J. Domestication of CIP-degrading bacterial consortium and preliminary study on their degradation characteristics[D]. Guangzhou: Jinan University, 2017.
[11]	Pan LJ, Li J, Li CX, et al. Study of ciprofloxacin biodegradation by a Thermus sp. isolated from pharmaceutical sludge[J]. J Hazard Mater, 2018, 343:59-67. doi: 10.1016/j.jhazmat.2017.09.009 URL
[12]	Nguyen LN, Nghiem LD, Oh S. Aerobic biotransformation of the antibiotic ciprofloxacin by Bradyrhizobium sp. isolated from activated sludge[J]. Chemosphere, 2018, 211:600-607. doi: S0045-6535(18)31472-3 pmid: 30096573
[13]	Liyanage GY, Manage PM. Removal of Ciprofloxacin(CIP)by bacteria isolated from hospital effluent water and identification of degradation pathways[J]. Int J Med Pharm Drug Res, 2018, 2(3):37-47.
[14]	疏文慧. 氧氟沙星厌氧降解菌的富集筛选和降解特性研究[D]. 无锡: 江南大学, 2021.
	Shu WH. Enrichment and isolation of anaerobic ofloxacin degradation bacteria and their degradation characteristics[D]. Wuxi: Jiangnan University, 2021.
[15]	Qu CX, Wu Z, Pan DD, et al. Characterization of Lactobacillus reuteri WQ-Y1 with the ciprofloxacin degradation ability[J]. Biotechnol Lett, 2021, 43(4):855-864. doi: 10.1007/s10529-020-03068-9 URL
[16]	Fang HT, Oberoi AS, He ZQ, et al. Ciprofloxacin-degrading Paraclostridium sp. isolated from sulfate-reducing bacteria-enriched sludge:Optimization and mechanism[J]. Water Res, 2021, 191:116808. doi: 10.1016/j.watres.2021.116808 URL
[17]	Parshikov IA, Heinze TM, Moody JD, et al. The fungus Pestalotiopsis guepini as a model for biotransformation of ciprofloxacin and norfloxacin[J]. Appl Microbiol Biotechnol, 2001, 56(3/4):474-477. doi: 10.1007/s002530100672 URL
[18]	Prieto A, Möder M, Rodil R, et al. Degradation of the antibiotics norfloxacin and ciprofloxacin by a white-rot fungus and identification of degradation products[J]. Bioresour Technol, 2011, 102(23):10987-10995. doi: 10.1016/j.biortech.2011.08.055 URL
[19]	Čvančarová M, Moeder M, Filipová A, et al. Biotransformation of fluoroquinolone antibiotics by ligninolytic fungi-Metabolites, enzymes and residual antibacterial activity[J]. Chemosphere, 2015, 136:311-320. doi: 10.1016/j.chemosphere.2014.12.012 pmid: 25592459
[20]	Singh SK, Khajuria R, Kaur L. Biodegradation of ciprofloxacin by white rot fungus Pleurotus ostreatus[J]. 3 Biotech, 2017, 7(1):69. doi: 10.1007/s13205-017-0684-y URL
[21]	Gao N, Liu CX, Xu QM, et al. Simultaneous removal of ciprofloxacin, norfloxacin, sulfamethoxazole by co-producing oxidative enzymes system of Phanerochaete chrysosporium and Pycnoporus sanguineus[J]. Chemosphere, 2018, 195:146-155. doi: 10.1016/j.chemosphere.2017.12.062 URL
[22]	Manasfi R, Chiron S, Montemurro N, et al. Biodegradation of fluoroquinolone antibiotics and the climbazole fungicide by Trichoderma species[J]. Environ Sci Pollut Res Int, 2020, 27(18):23331-23341. doi: 10.1007/s11356-020-08442-8 URL
[23]	Adjei MD, Heinze TM, Deck J, et al. Transformation of the antibacterial agent norfloxacin by environmental mycobacteria[J]. Appl Environ Microbiol, 2006, 72(9):5790-5793. doi: 10.1128/AEM.03032-05 URL
[24]	付泊明, 陈立伟, 蔡天明, 等. 诺氟沙星降解菌NOR-36的分离筛选及降解特性研究[J]. 环境科学学报, 2017, 37(2):576-584.
	Fu BM, Chen LW, Cai TM, et al. Isolation and characterization of norfloxacin-degrading bacterium strain NOR-36[J]. Acta Sci Circumstantiae, 2017, 37(2):576-584.
[25]	王强锋, 朱彭玲, 夏中梅, 等. 三种农用抗生素降解真菌的筛选及其降解性能[J]. 农业资源与环境学报, 2018, 35(6):533-539.
	Wang QF, Zhu PL, Xia ZM, et al. Screening and degradation properties of three kinds of agricultural antibiotics degrading fungi[J]. J Agric Resour Environ, 2018, 35(6):533-539.
[26]	Li KJ, Xu AL, Wu DH, et al. Degradation of ofloxacin by a manganese-oxidizing bacterium Pseudomonas sp. F2 and its biogenic manganese oxides[J]. Bioresour Technol, 2021, 328:124826. doi: 10.1016/j.biortech.2021.124826 URL
[27]	Maia AS, Tiritan ME, Castro PML. Enantioselective degradation of ofloxacin and levofloxacin by the bacterial strains Labrys portucalensis F11 and Rhodococcus sp. FP₁[J]. Ecotoxicol Environ Saf, 2018, 155:144-151. doi: 10.1016/j.ecoenv.2018.02.067 URL
[28]	梅瀚杰, 陈喜鸿, 胡文锋, 等. 一株降解恩诺沙星菌株的筛选鉴定及其降解条件的优化[J]. 食品工业科技, 2021, 42(5):105-112.
	Mei HJ, Chen XH, Hu WF, et al. Screening and identification of enrofloxacin degrading strain and optimization of its degradation conditions[J]. Sci Technol Food Ind, 2021, 42(5):105-112.
[29]	Wetzstein HG, Schneider J, Karl W. Patterns of metabolites produced from the fluoroquinolone enrofloxacin by basidiomycetes indigenous to agricultural sites[J]. Appl Microbiol Biotechnol, 2006, 71(1):90-100. pmid: 16328445
[30]	Maia AS, Ribeiro AR, Amorim CL, et al. Degradation of fluoroquinolone antibiotics and identification of metabolites/transformation products by liquid chromatography-tandem mass spectrometry[J]. J Chromatogr A, 2014, 1333:87-98. doi: 10.1016/j.chroma.2014.01.069 pmid: 24548434
[31]	Feng NX, Yu J, Xiang L, et al. Co-metabolic degradation of the antibiotic ciprofloxacin by the enriched bacterial consortium XG and its bacterial community composition[J]. Sci Total Environ, 2019, 665:41-51. doi: 10.1016/j.scitotenv.2019.01.322 URL
[32]	Blánquez A, Guillén F, Rodríguez J, et al. The degradation of two fluoroquinolone based antimicrobials by SilA, an alkaline laccase from Streptomyces ipomoeae[J]. World J Microbiol Biotechnol, 2016, 32(3):52. doi: 10.1007/s11274-016-2032-5 URL
[33]	Mathur P, Sanyal D, Dey P. The optimization of enzymatic oxidation of levofloxacin, a fluoroquinolone antibiotic for wastetwater treatment[J]. Biodegradation, 2021, 32(4):467-485. doi: 10.1007/s10532-021-09946-x URL
[34]	Lueangjaroenkit P, Teerapatsakul C, Sakka K, et al. Two manganese peroxidases and a laccase of Trametes polyzona KU-RNW027 with novel properties for dye and pharmaceutical product degradation in redox mediator-free system[J]. Mycobiology, 2019, 47(2):217-229. doi: 10.1080/12298093.2019.1589900 pmid: 31448142
[35]	Jia YY, Khanal SK, Shu HY, et al. Ciprofloxacin degradation in anaerobic sulfate-reducing bacteria(SRB)sludge system:mechanism and pathways[J]. Water Res, 2018, 136:64-74. doi: 10.1016/j.watres.2018.02.057 URL
[36]	Park CH, Robicsek A, Jacoby GA, et al. Prevalence in the United States of aac(6 ‘)- Ib - cr encoding a ciprofloxacin-modifying enzyme[J]. Antimicrob Agents Chemother, 2006, 50(11):3953-3955. pmid: 16954321
[37]	Ingram PR, Rogers BA, Sidjabat HE, et al. Co-selection may explain high rates of ciprofloxacin non-susceptible Escherichia coli from retail poultry reared without prior fluoroquinolone exposure[J]. J Med Microbiol, 2013, 62(Pt 11):1743-1746. doi: 10.1099/jmm.0.062729-0 URL
[38]	Zhao RN, Li XH, Hu MC, et al. Efficient enzymatic degradation used as pre-stage treatment for norfloxacin removal by activated sludge[J]. Bioprocess Biosyst Eng, 2017, 40(8):1261-1270. doi: 10.1007/s00449-017-1786-y URL
[39]	Asgher M, Bhatti HN, Ashraf M, et al. Recent developments in biodegradation of industrial pollutants by white rot fungi and their enzyme system[J]. Biodegradation, 2008, 19(6):771-783. doi: 10.1007/s10532-008-9185-3 pmid: 18373237
[40]	Reis AC, Kolvenbach BA, Nunes OC, et al. Biodegradation of antibiotics:the new resistance determinants - part II[J]. N Biotechnol, 2020, 54:13-27. doi: 10.1016/j.nbt.2019.08.003 URL
[41]	Rusch M, Spielmeyer A, Zorn H, et al. Biotransformation of ciprofloxacin by Xylaria longipes:structure elucidation and residual antibacterial activity of metabolites[J]. Appl Microbiol Biotechnol, 2018, 102(19):8573-8584. doi: 10.1007/s00253-018-9231-y URL
[42]	夏湘勤, 黄彩红, 席北斗, 等. 畜禽粪便中氟喹诺酮类抗生素的生物转化与机制研究进展[J]. 农业环境科学学报, 2019, 38(2):257-267.
	Xia XQ, Huang CH, Xi BD, et al. Review on biotransformation and mechanism of fluoroquinolone antibiotics from livestock manure[J]. J Agro Environ Sci, 2019, 38(2):257-267.
[43]	Mathur P, Sanyal D, Callahan DL, et al. Treatment technologies to mitigate the harmful effects of recalcitrant fluoroquinolone antibiotics on the environ- ment and human health[J]. Environ Pollut, 2021, 291:118233. doi: 10.1016/j.envpol.2021.118233 URL
[44]	Liao XB, Li BX, Zou RS, et al. Biodegradation of antibiotic ciprofloxacin:pathways, influential factors, and bacterial community structure[J]. Environ Sci Pollut Res Int, 2016, 23(8):7911-7918. doi: 10.1007/s11356-016-6054-1 URL
[45]	Kim DW, Heinze TM, Kim BS, et al. Modification of norfloxacin by a Microbacterium sp. strain isolated from a wastewater treatment plant[J]. Appl Environ Microbiol, 2011, 77(17):6100-6108. doi: 10.1128/AEM.00545-11 URL
[46]	Zhao CY, Ru SG, Cui PF, et al. Multiple metabolic pathways of enrofloxacin by Lolium perenne L. :Ecotoxicity, biodegradation, and key driven genes[J]. Water Res, 2021, 202:117413. doi: 10.1016/j.watres.2021.117413 URL
[47]	Wang L, Qiang ZM, Li YG, et al. An insight into the removal of fluoroquinolones in activated sludge process:Sorption and biodegradation characteristics[J]. J Environ Sci(China), 2017, 56:263-271.
[48]	陈国鑫. 水产养殖水中抗生素的残留特性及其去除技术研究[D]. 广州: 广东工业大学, 2015.
	Chen GX. Study on residual characterization of antibiotics in aquaculture wastewater and its removal technology[D]. Guangzhou: Guangdong University of Technology, 2015.
[49]	王亚军, 陈甜婧. 氟喹诺酮类抗生素在水环境中的去除研究综评[J]. 环境监测管理与技术, 2021, 33(5):1-5.
	Wang YJ, Chen TJ. Comprehensive review on the removal of fluoroquinolone antibiotics in water environment[J]. Adm Tech Environ Monit, 2021, 33(5):1-5.
[50]	张全胜. 影响活性污泥法处理效果的因素[J]. 四川建材, 2021, 47(7):34-35.
	Zhang QS. Factors affecting the effect of activated sludge treatment[J]. Sichuan Build Mater, 2021, 47(7):34-35.
[51]	公言飞, 刘鹏, 郅立鹏. 膜生物反应器(MBR)研究现状及发展趋势[J]. 中国资源综合利用, 2021, 39(3):90-93.
	Gong YF, Liu P, Zhi LP. Research status and development trend of membrane bioreactor(MBR)[J]. China Resour Compr Util, 2021, 39(3):90-93.
[52]	Dorival-García N, Zafra-Gómez A, Navalón A, et al. Removal of quinolone antibiotics from wastewaters by sorption and biological degradation in laboratory-scale membrane bioreactors[J]. Sci Total Environ, 2013, 442:317-328. doi: 10.1016/j.scitotenv.2012.10.026 URL
[53]	Xu ZC, Song XY, Li Y, et al. Removal of antibiotics by sequencing-batch membrane bioreactor for swine wastewater treatment[J]. Sci Total Environ, 2019, 684:23-30. doi: 10.1016/j.scitotenv.2019.05.241 URL
[54]	覃宁波. 膜生物反应器污水处理技术的研究进展[J]. 大众科技, 2021, 23(6):13-15.
	Qin NB. Research progress of membrane bioreactor wastewater treatment technology[J]. Pop Sci Technol, 2021, 23(6):13-15.
[55]	杨鑫, 赵国淼, 朱威宇, 等. 酸碱指示剂在工业微生物高通量筛选中的应用进展[J]. 发酵科技通讯, 2021, 50(4):223-227.
	Yang X, Zhao GM, Zhu WY, et al. Application progress of acid-base indicators in high-throughput screening of industrial microorganisms[J]. Bull Ferment Sci Technol, 2021, 50(4):223-227.
[56]	黄佳城, 张瑷珲, 付友思, 等. 功能性菌群构建的研究进展[J]. 合成生物学, 2022, 3(1):155-167.
	Huang JC, Zhang AH, Fu YS, et al. Research progress in construction of functional microbial communities[J]. Synth Biol J, 2022, 3(1):155-167.
[57]	黄慧. 四氢呋喃降解菌群的富集与重建及降解菌ZM07与非降解菌互作机制研究[D]. 杭州: 浙江大学, 2021.
	Huang H. Enrichment and reconstruction of tetrahydrofuran-degrading microbial culture and interactions between degrading bacterium ZM07 and non-degrading bacteria[D]. Hangzhou: Zhejiang University, 2021.
[58]	徐昭勇, 胡海洋, 许平, 等. 人工合成微生物组的构建与应用[J]. 合成生物学, 2021, 2(2):181-193.
	Xu ZY, Hu HY, Xu P, et al. Development and application of synthetic microbiome[J]. Synth Biol J, 2021, 2(2):181-193.
[59]	王肖. 复合MBR强化去除污水中残留抗生素的效果研究[D]. 南京: 东南大学, 2015.
	Wang X. Research on the enhanced removal of antibiotic residues in wastewater by new composite MBR[D]. Nanjing: Southeast University, 2015.
[60]	Zhao X, Tian FW, Wang G, et al. Isolation, identification and characterization of human intestinal bacteria with the ability to utilize chloramphenicol as the sole source of carbon and energy[J]. FEMS Microbiol Ecol, 2012, 82(3):703-712. doi: 10.1111/j.1574-6941.2012.01440.x pmid: 22757630
[61]	Barnhill AE, Weeks KE, Xiong N, et al. Identification of multiresistant Salmonella isolates capable of subsisting on antibiotics[J]. Appl Environ Microbiol, 2010, 76(8):2678-2680. doi: 10.1128/AEM.02516-09 URL

氟喹诺酮类抗生素 Fluoroquinolone antibiotics	菌株 Strains	初始浓度 Initial concentration/（mg·L^-1）	降解率 Degradation rate /%	参考文献Reference
环丙沙星Ciprofloxacin	细菌Bacteria
环丙沙星Ciprofloxacin	Labrys portucalensis F11	1.15	85（28 d）	[9]
	Ochrobactrum sp. JOB	10	34（14 d）	[10]
	Thermus thermophiles C419	5	57（5 d）	[11]
	Bradyrhizobium sp. GLC_01	0.05	70（8 d）	[12]
	Bacillus sp. KM504129	5	74（14 d）	[13]
	Bacillus subtilius	5	70（14 d）	[13]
	Enterobacter sp. KM504128	5	94（14 d）	[13]
	Lactobacillus gesseri KM4055978	5	100（14 d）	[13]
	Micrococcus luteus	5	56（14 d）	[13]
	Tepidiphilus sp. M4	30	49（10 d）	[14]
	Lactobacillus reuteri WQ-Y1	4	65（1 d）	[15]
	Paraclostridium sp.	5	74（3 d）	[16]
	真菌Fungi
	Pestalotiopsis guepini P-8	100	67.7（18 d）	[17]
	Trametes versicolor ATCC42530	2	90（7 d）	[18]
	Trametes versicolor 617/93	10	100（14 d）	[19]
	Irpex lacteus 617/93	10	100（10 d）	[19]
	Panus tigrinus 577.79	10	60（14 d）	[19]
	Pleurotus ostreatus	1.50	95.07（14 d）	[20]
	Pycnoporus sanguineus CGMCC 5.815	10	98.5（2 d）	[21]
	Phanerochaete chrysosporium CGMCC 5.776	10	64.5（8 d）	[21]
	Trichoderma asperellum	0.20	81（13 d）	[22]
	Trichoderma harzianum	0.20	21（13 d）	[22]
诺氟沙星Norfloxacin	细菌Bacteria
	Labrys portucalensis F11	1.11	85（28 d）	[9]
	Mycobacterium sp.	100	75-98.4（7 d）	[23]
	Staphylococcus capraeNOR-36	5	92.6（10 d）	[24]
	Thermus thermophiles C419	5	63（72 h）	[10]
	Tepidiphilus sp. M4	30	51（10 d）	[14]
	Paraclostridium sp.	5	60（3 d）	[16]
	真菌Fungi
	Pestalotiopsis guepini P-8	100	68.9（18 d）	[17]
	Trametes versicolor ATCC42530	2	90（7 d）	[18]
	Trametes versicolor 617/93	10	85（14 d）	[19]
	Irpex lacteus 617/93	10	100（10 d）	[19]
	Pycnoporus sanguineus CGMCC 5.815	10	96.4（2 d）	[21]
	Phanerochaete chrysosporium CGMCC 5.776	10	73.2（8 d）	[21]
	Fusarium verticillioides MH045733	50	37.54（7 d）	[25]
	Fusarium solani MH045734	50	33.59（7 d）	[25]
	Aspergillus sydowii MH045735	50	15.67（7 d）	[25]
	Penicillium janthinellum MH045736	50	46.31（7 d）	[25]
氧氟沙星Ofloxacin	细菌Bacteria
	Thermus thermophiles C419	5	70（72 h）	[11]
	Tepidiphilus sp. M4	30	47（10 d）	[14]
	Paraclostridium sp.	5	68（3 d）	[16]
	Pseudomonas sp. F2	5	100	[26]
	Labrys portucalensis F11	0.45	34.6（28 d）	[27]
	Rhodococcus sp. FP1	0.45	39.3（28 d）	[27]
	真菌Fungi
	Trametes versicolor 617/93	10	100（14 d）	[19]
	Irpex lacteus 617/93	10	100（10 d）	[19]
	Trichoderma asperellum	0.20	44（13 d）	[22]
	Trichoderma harzianum	0.20	32（13 d）	[22]
恩诺沙星Enrofloxacin	细菌Bacteria
	Thermus thermophiles C419	5	74（72 h）	[11]
	Paraclostridium sp.	5	68（3 d）	[16]
	Enterococcus faecalis BSFL-1	100	63.2（96 h）	[28]
	Proteus mirabilis BSFL-2	100	57.2（96 h）	[28]
	Enterococcus faecalis BSFL-3	100	65.9（96 h）	[28]
	真菌Fungi
	Agrocybe praecox	——	——	[29]
	Coprinus macrocephalus	——	——	[29]
	Cyathus stercoreus	——	——	[29]

氟喹诺酮类抗生素 Fluoroquinolone antibiotics	菌株 Strains	初始浓度 Initial concentration/（mg·L^-1）	降解率 Degradation rate /%	参考文献Reference
环丙沙星Ciprofloxacin	细菌Bacteria
环丙沙星Ciprofloxacin	Labrys portucalensis F11	1.15	85（28 d）	[9]
	Ochrobactrum sp. JOB	10	34（14 d）	[10]
	Thermus thermophiles C419	5	57（5 d）	[11]
	Bradyrhizobium sp. GLC_01	0.05	70（8 d）	[12]
	Bacillus sp. KM504129	5	74（14 d）	[13]
	Bacillus subtilius	5	70（14 d）	[13]
	Enterobacter sp. KM504128	5	94（14 d）	[13]
	Lactobacillus gesseri KM4055978	5	100（14 d）	[13]
	Micrococcus luteus	5	56（14 d）	[13]
	Tepidiphilus sp. M4	30	49（10 d）	[14]
	Lactobacillus reuteri WQ-Y1	4	65（1 d）	[15]
	Paraclostridium sp.	5	74（3 d）	[16]
	真菌Fungi
	Pestalotiopsis guepini P-8	100	67.7（18 d）	[17]
	Trametes versicolor ATCC42530	2	90（7 d）	[18]
	Trametes versicolor 617/93	10	100（14 d）	[19]
	Irpex lacteus 617/93	10	100（10 d）	[19]
	Panus tigrinus 577.79	10	60（14 d）	[19]
	Pleurotus ostreatus	1.50	95.07（14 d）	[20]
	Pycnoporus sanguineus CGMCC 5.815	10	98.5（2 d）	[21]
	Phanerochaete chrysosporium CGMCC 5.776	10	64.5（8 d）	[21]
	Trichoderma asperellum	0.20	81（13 d）	[22]
	Trichoderma harzianum	0.20	21（13 d）	[22]
诺氟沙星Norfloxacin	细菌Bacteria
	Labrys portucalensis F11	1.11	85（28 d）	[9]
	Mycobacterium sp.	100	75-98.4（7 d）	[23]
	Staphylococcus capraeNOR-36	5	92.6（10 d）	[24]
	Thermus thermophiles C419	5	63（72 h）	[10]
	Tepidiphilus sp. M4	30	51（10 d）	[14]
	Paraclostridium sp.	5	60（3 d）	[16]
	真菌Fungi
	Pestalotiopsis guepini P-8	100	68.9（18 d）	[17]
	Trametes versicolor ATCC42530	2	90（7 d）	[18]
	Trametes versicolor 617/93	10	85（14 d）	[19]
	Irpex lacteus 617/93	10	100（10 d）	[19]
	Pycnoporus sanguineus CGMCC 5.815	10	96.4（2 d）	[21]
	Phanerochaete chrysosporium CGMCC 5.776	10	73.2（8 d）	[21]
	Fusarium verticillioides MH045733	50	37.54（7 d）	[25]
	Fusarium solani MH045734	50	33.59（7 d）	[25]
	Aspergillus sydowii MH045735	50	15.67（7 d）	[25]
	Penicillium janthinellum MH045736	50	46.31（7 d）	[25]
氧氟沙星Ofloxacin	细菌Bacteria
	Thermus thermophiles C419	5	70（72 h）	[11]
	Tepidiphilus sp. M4	30	47（10 d）	[14]
	Paraclostridium sp.	5	68（3 d）	[16]
	Pseudomonas sp. F2	5	100	[26]
	Labrys portucalensis F11	0.45	34.6（28 d）	[27]
	Rhodococcus sp. FP1	0.45	39.3（28 d）	[27]
	真菌Fungi
	Trametes versicolor 617/93	10	100（14 d）	[19]
	Irpex lacteus 617/93	10	100（10 d）	[19]
	Trichoderma asperellum	0.20	44（13 d）	[22]
	Trichoderma harzianum	0.20	32（13 d）	[22]
恩诺沙星Enrofloxacin	细菌Bacteria
	Thermus thermophiles C419	5	74（72 h）	[11]
	Paraclostridium sp.	5	68（3 d）	[16]
	Enterococcus faecalis BSFL-1	100	63.2（96 h）	[28]
	Proteus mirabilis BSFL-2	100	57.2（96 h）	[28]
	Enterococcus faecalis BSFL-3	100	65.9（96 h）	[28]
	真菌Fungi
	Agrocybe praecox	——	——	[29]
	Coprinus macrocephalus	——	——	[29]
	Cyathus stercoreus	——	——	[29]