Biotechnology Bulletin ›› 2023, Vol. 39 ›› Issue (3): 69-80.doi: 10.13560/j.cnki.biotech.bull.1985.2022-0793

Previous Articles     Next Articles

Application of Lipidomics in Toxicological Studies

WANG Xin-lu(), WANG Meng(), ZHAI Wen-lei   

  1. Institute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097
  • Received:2022-06-28 Online:2023-03-26 Published:2023-04-10

Abstract:

As major components of cells, lipids play important roles in a variety of life activities, such as intracellular material transport, signal transduction and apoptosis, etc. Lipidomics provides a systematic analysis of lipids in living organisms to understand their interactions and the interactions with other biomolecules. The authors mainly introduced the analysis methods of lipidomics, including the pretreatment methods of samples, detection methods and instruments, and data analysis methods. Besides that, the authors reviewed the research progress of lipidomics in neurotoxicity, hepatotoxicity, immunotoxicity and endocrine disrupting toxicity, aiming to provide ideas and reference for studying the mechanism of compound toxicity. Finally, the authors suggested that lipidomics technology should be used to study the combined toxic effects of different compounds in the future, to screen relevant lipid biomarkers based on the lipidomics, as well as to provide the scientific basis for risk warning of combined toxicity and relevant toxic mechanism study.

Key words: lipids, lipidomics, toxicology, analysis methods