Fig. 1 Effects of crude extracts from five strains of symbiotic fungi on NO production in BV-2 cells under brown rice medium conditions “#” indicates a significant stimulatory effect of LPS on cells compared to the control group, ####: P<0.000 1; “*” indicates that the crude extract of the strain is significantly different at that concentration, *: P<0.05, ****: P<0.000 1. The same below

Fig. 2 Effect of crude extracts of five strains of symbiotic fungi on the viability and survival of BV-2 cells under brown rice medium conditions

Fig. 3 Growth morphology of five strains with anti-inflammatory activity

Fig. 4 TLC fingerprinting and iron trichloride-potassium ferricyanide color development of the crude extracts from five strains A, B, C, D and E indicate strains C1-5, C3-3, C3-8, C3-9 and C14-17, respectively. 1, 2 and 3 are the 254 nm UV image, 365 nm fluorescence image and iron trichloride-potassium ferricyanide color development image of each crude extract, respectively; and 1-9 below indicate 0.3% salinity PDB medium ethyl acetate extract, 0.3% salinity PDB medium methanolic extract, 3% salinity PDB medium ethyl acetate extract, 3% salinity PDB medium methanolic extract, 10% salinity PDB medium ethyl acetate extract, 10% salinity PDB medium methanolic extract, 0.3% salinity brown rice medium methanolic extract, 3% salinity brown rice medium methanolic extract and 10% salinity brown rice medium methanolic，respectively

Fig. 5 LC-MS/MS base-peak chromatograms of the fermented products of strain C3-9 under different culture conditions

Fig. 6 Local magnification of metabolites of strain C3-9 in 0.3% and 10% salinity brown rice medium based on secondary mass spectrometric correlation of molecular network Each node indicates the average mass with the same molecular ionic mass, and different colored cross sections in the nodes indicate different samples, indicating brown rice medium at 3% salinity and brown rice medium at 10% salinity, respectively