Progress in the Mechanism of Host Cell Apoptosis Induced by Pathogen Virulence Factors

Abstract

Abstract: Apoptosis may occurs under pathological conditions and is sometimes accompanied by necrosis. In particular, bacterial infections play an important role in triggering apoptosis. Pathogenic bacteria can trigger apoptosis by activating some factor or suppress inhibitors of apoptosis, then change the host cell signaling pathways and induce cell apoptosis. In recent years, researchers have found that cell apoptosis is mainly related to pathogenic bacteria of virulence factor. Here, we reviewed the mechanism of host cell apoptosis induced by pathogen virulence factors, which aims at revealing the integrated effects of bacterial virulence factor triggering host apoptosis, and the same kind of bacteria can trigger to cell apoptosis through different mechanisms. Finally, with the help of current research progress and our own studies, we discussed and prospected pathogen virulence factor induced host cell apoptosis mechanism and application prospect, and discovered the pathogen virulence factor is of great potential in cancer and some bacterial resistant diseases.

Key words: Bacteria, Virulence, Factor, Host cell, Apoptosis

Hu Qingliang, Li Lingjuan, Wang Xiao. Progress in the Mechanism of Host Cell Apoptosis Induced by Pathogen Virulence Factors[J]. Biotechnology Bulletin, 2013, 0(6): 32-38.

References

[1] Lancellotti M, Pereira RF, Cury G, et al. Pathogenic and opportunistic respiratory bacteria-induced apoptosis[J]. Braz J Infect Dis, 2009, 13(3):226-31.
[2] Higgs BW, Dileo J, Chang WE, et al. Modeling the effects of a Stap-hylococcal Enterotoxin B (SEB)on the apoptosis pathway[J]. BMC Microbiol, 2006, 6(1):48-59.
[3] Shinohara F, Sato K, Suzuki M, et al. Role of caspase in CD80 expression of superantigen-stimulated monocytes[J]. Int J Mol Med, 2004, 14(2):241-246.
[4] Ruiz-Ruz C, Ruiz de Almodovar C, Rodriguez A, et al. The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1[J]. J Biol Chem, 2004, 279(19):19712-19720.
[5] Genestier AL, Michallet MC, Prévost G, et al. Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils[J]. J Clin Invest, 2005, 115(11):3117-3127.
[6] Skals M, Leipziger J, Praetorius HA. Haemolysis induced by α-toxin from Staphylococcus aureus requires P2X receptor activation[J]. Pflugers Arch, 2011, 462(5):669-679.
[7] Jonas D, Walev I, Berger T, et al. Novel path to apoptosis:Small transmembrane pores created by staphylococcal alpha-toxin in Tlymphocytes evoke internucleosomal DNA degradation[J]. InfectImmun, 1994, 62(4):301-304.
[8] Bantel H, Sinha B, Domschke W, et al. alpha-Toxin is a mediator of Staphylococcus aureus induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling[J]. J Cell Biol, 2001, 155(4):637-648.
[9] Norén T. Clostridium difficile and the disease it causes[J]. Methods Mol Biol, 2010;646:9-35.
[10] 刘小红, 沈阳. 艰难梭菌毒素A对胆管癌细胞株 FRH-0201 增殖和凋亡的影响 . 现代生物医学进展, 2011, 60:1673-6273.
[11] Li P, Chen C, Xi YM, et al. Apoptosis-inducing effect of clostridium difficile toxin A on K562 cells and its mechanism[J]. Zhong guo Shi Yan Xue Ye Xue Za Zhi, 2011, 19(3):638-642.
[12] Morimoto H, Bonarida S. Diphtheria toxin and Pseudomonas alldon toxin mediated apoptosis[J]. J Immnol, 1992, 149(6):2089-2094.
[13] Bassinet L, Fitting C, Housset B, et al. Bordetella pertussis adenylate cyclase-hemolysin induces interleukin-6 secretion by human tracheal epithelial cells[J]. Infect Immun, 2004, 72(9):5530-5533.
[14] Ohnishi H, Miyake M, Kamitani S, et al. The morphological changes in cultured cells caused by Bordetella pertussis adenylate cyclase toxin[J]. FEMS Microbiol Lett, 2008, 279(2):174-179.
[15] Gray MC, Donato GM, Jones FR, et al. Newly secreted adenylatecy-clase toxin is responsible for intoxication of target cells by Bordete-lla pertussis[J]. Mol Microbiol, 2004, 53(6):1709-1719.
[16] Hewlett EL, Donato GM, Gray MC. Macrophage cytotoxicity prod-uced by adenylate cyclase toxin from Bordetella pertussis:more than just making cyclic AMP[J]. Mol Microbiol, 2006, 59(2):447-459.
[17] Knapp O, Maier E, Masín J, et al. Pore formation by the Bordetella adenylate cyclase toxin in lipid bilayer membranes:role of voltage and Ph[J]. Biochim Biophys Acta, 2008, 1778(1):260-269.
[18] Ohnishi H, Miyake M, Kamitani S, et al. The morphological changes in cultured cells caused by Bordetella pertussis adenylatecyclase toxin[J]. FEMS Microbiol Lett, 2008, 279(2):174-179.
[19] Nakagawa I, Nakata M, Kawabata S, et al. Regulated expression of the Shiga toxin B gene induces apoptosis in mammalian fibroblastic cells[J]. Mol Microbiol, 1999, 33(6):1190-1199.
[20] Lentz EK, Leyva-Illades D, Lee MS, et al. Differential response of the human renal proximal tubular epithelial cell line HK-2 to Shiga toxin types 1 and 2[J]. Infect Immun, 2011, 79:3527-3540.
[21] Lee SY, Lee MS, Cherla RP, Tesh VL. Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells[J]. Cell Microbiol, 2008, 10:770-780.
[22] Pijpers AH, van Setten PA, van den Heuvel LP, et al. Verocytotoxin-induced apoptosis of human microvascular endothelial cells[J]. J Am Soc Nephrol, 2001, 12(4):767-778.
[23] LI H, Wang JH, HE P, et al . Mechanism and effect of Escherichia coli infection on apoptosis of U937 cell[J]. Journal of Xinxiang Medical College, 2011, 28(3):276-278.
[24] Chai J, Du C, Wu J W, et al. Structural and biochemical basis of apoptosis activation by Smac / DIABL[J]. Nature, 2000, 406(6798):855-862.
[25] 仇文颖, 王兴翠, 尚宏伟, 等. 内毒素所致SIRS/ MODES小鼠脾细胞损伤的形态学观察[J]. 中国组织化学与细胞化学, 2002, 11(2):142-145.
[26] Matsuno K, Iwata K, Matsumoto M, et al. NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis[J]. Free Radic Biol Med, 2012, 53(9):1718-1728.
[27] Chin AC, Flynn AN, Fedwick JP, et al. The role of caspase-3 in lipopolysacc haride-mediated disruption of intestinal epithelial tight junctions[J]. Can J Physiol Pharmacol, 2006, 84 (10):1043-1050.
[28] 刘婷婷, 马丽娜, 李凤云, 等. 伤寒沙门菌诱导巨噬细胞凋亡机制的探讨[J]. 中国人兽共患病学报, 2010, 26 (3):239-242.
[29] Panaro MA, Pricci M, Meziani F, et al. Cyclooxygenase-2-derived prostacyclin protective role on endotoxin-induced mouse card-iomyocyte mortality[J]. Cardiovasc Toxicol, 2011, 11(4):347-356.
[30] 孙阳, 李凤云, 王朝夫, 等 . 痢疾志贺菌D15及其L型内毒素致细胞凋亡的研究[J]. 蚌埠医学院学报, 2002, 27(4):287-294.
[31] Hilbi H, Moss J, Hersh D, et al. Shigella-induced apoptosis dependent on caspaes-1 which binds to IpaB[J] . J Biol Chem, 1998, 273:32895-32900.
[32] Mantis N, Prevost MC, Sansonetti P. Analysis of epithelial cell stress response during infection by Shigella Flexner i [J]. Infect Immun, 1996, 64:2474-2482.
[33] Scheuring UJ. Sabzevari H, Corbeil J, et al. Differential expression profiles of apoptosis affecting genes in HIV-infected cell lines and patients T cells[J]. AIDS, 1999, 13(2):167-175.
[34] Trulzsch K, Geginat G, Sporleder T, et al. Yersinia outer protein P inhibits CD8 T cell priming in the mouse infection model[J] . J Immunol, 2005, 174(7):4244-4251.
[35] Lancellotti M, BrocchiM, da Silveira WD . Bacteria-induced apoptosis:An approach to bacterial pathogenesis[J]. Braz J Morphol, Sci, 2006, 23(1):75-86.
[36] Zhao YX, Lajoie G, Zhang H, et al. Tumor necrosis factor receptor p55-deficient mice respond to acute Yersinia enterocolitica infection with less apoptosis and more effective host resistance[J]. Infect Immunol, 2000, 68(3):1243-1251.
[37] Pandey AK, Sodhi A. Recombinant YopJ induces apoptosis in murine peritoneal macrophages in vitro:involvement of mitochondrial death pathway[J]. Int Immunol, 2009, 21 (11):1239-1249.
[38] Hao YH, Wang Y, Burdette D, et al. Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways[J]. PLoS One, 2008, 23(1):1375.
[39] Ricote M, Garcia-Tunon I, Fraile B, et al. P38 MAPK protects against TNF-alpha-provoked apoptosis in LNCaP prostatic cancer cells[J]. Apoptosis, 2006, 11(11):1969-1975.
[40] Hersh D, Monack DM, Smith MR, et al. The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1[J]. Proc Natl Acad Sci USA, 1999, 96(5):2396-2401.
[41] Huang R, Wu S, Zhang X, et al. Molecular analysis and identifica-tion of virulence gene on pRST98 from multi-drug resistant Salmo-nella typhi[J]. Cell & Mol Immunol, 2005, 2(2):136-140.
[42] Browne SH, Hasegawa P, Okamoto S, et al. Identification of Salmonella SPI-2 secretion system components required for SpvB-mediated cytotoxicity in macrophages and virulence in mice[J]. FEMS Immunol Med Microbiol, 2008, 52(2):194-201.
[43] Miethke T, Wahl C, Heeg K, et al. T cell mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B:critical role of tumor necrosis factor[J]. J Exp Med, 1992, 175:91-98.
[44] Xu SX, Mc Cormick JK. Staphylococcal superantigens in colonization and disease[J]. Front Cell Infect Microbiol, 2012, 2:52-57.
[45] Van Zele T, Gevaert P. Role of Staphylococcus aureus in upper respiratory infections[J]. Verh K Acad Geneeskd Belg, 2008, 70(5-6):369-378.
[46] 王红兵, 杨策尧, 曾卫玲. 超抗原SPE对SLE患者外周血T淋巴细胞增殖和凋亡作用的研究[J]. 中国皮肤性病学杂志, 2005, 19 (7):395-397.
[47] Dauwalder O, Pachot A, Cazalis MA, et al. Early kinetics of the transcriptional response of human leukocytes to staphylococcal superantigenic enterotoxins A and G[J]. Microb Pathog, 2009, 47(3):171-176.
[48] HanCH, Gong Z, Hao L, et al. Mechanism of Monoclonal antibody-coupled Staphylococcus superantigen-a induced apoptosis in human bladder cancer cells[J]. Cell Biochemistry and Biophysics, 2011, 61 (3):679-684.
[49] Towhid ST, Nega M, Schmidt EM, et al. Stimulation of platelet apoptosis by peptidoglycan from Staphylococcus aureus 113[J]. Apoptosis,  2012, 17(9):998-1008.
[50] Engedal N, Skotland T, Torgersen M L, et al. Shiga toxin andits use in targeted cancer therapy and imaging. Microb[J]. Biotechnol, 2011, 4:32-46.