Screening and Characterization of a Marine Actinomycete with Antagonist Activities Against Multidrug Resistant Bacteria

Abstract

Abstract: It was to screening the antagonist activities against multidrug resistant bacteria from 71 marine actinomycetes. The inhibitory effect of 71 marine actinomycetes were detected against multidrug resistant bacteria by disk diffusion method, the strain was identified by morphological, physiological, biochemical characteristics and 16S rDNA sequence analysis. Results showed that strain MQ-86 showed strong inhibitory effect against multidrug resistant bacteria. The fermentation crude extract of strain MQ-86 using M₂₊ medium shows strong inhibitory effect to Escherichia coli 8739, Staphylococcus aureus 6538, Candida albicans 10231, Escherichia coli 480, Escherichia coli 460 and Staphylococcus aureus 206. Strain MQ-86 has a strong inhibitory effect against multidrug resistant organisms, which was identified as Streptomyces parvus.

Key words: Marine actinomycetes, Antibacterial activity, Streptomyces, Multidrug resistant bacteria

Chen Meiqun，Feng Guangda,Deng Mingrong,Zhu Honghui. Screening and Characterization of a Marine Actinomycete with Antagonist Activities Against Multidrug Resistant Bacteria[J]. Biotechnology Bulletin, 2013, 0(7): 119-124.

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