Progress on Antibacterial Mechanism,Activity and Application of Silver Nanoclusters

doi:10.13560/j.cnki.biotech.bull.1985.2020-0828

Abstract

Abstract:

Silver nanoclusters are a class of silver nanomaterials whose particle sizes are between silver atoms and silver nanoparticles and consist of several to hundreds of silver atoms at a core size of less than 2 nm. In recent years,silver nanoclusters have attracted much attention in the field of antimicrobial application due to their inherent advantages such as broad-spectrum antibacterial activity,non-drug resistance,good biocompatibility and low dose effectiveness. In this paper,the antibacterial mechanisms and influencing factors of antibacterial activity of silver nanoclusters are reviewed,their cytotoxicity is discussed,and the existing antibacterial applications are summarized. The future application directions and breakthroughs of silver nanoclusters are prospected,and the wide application prospects of DNA silver nanoclusters are highlighted.

Key words: silver nanoclusters, antibacterial mechanism, antibacterial activity, cytotoxicity, DNA

GONG Xiao-hui, YANG Min, LI Shu-ting, LIN Sheng-hao, XU Wen-tao. Progress on Antibacterial Mechanism,Activity and Application of Silver Nanoclusters[J]. Biotechnology Bulletin, 2021, 37(5): 212-220.

Figures/Tables 4

Fig. 1 Routes of antibacterial action of AgNPs

Fig. 2 Schematic diagram of antibacterial mechanism of AgNCs against Escherichia coli

Fig. 3 Schematic diagram of in situ impregnation of AgNCs in microporous CS-PEG membranes

Fig. 4 Schematic diagram of synthetic process and struc-ture of Y-super-NC, X-super-NC, and (Y-X)-super-NC

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