生物技术通报 ›› 2020, Vol. 36 ›› Issue (4): 175-184.doi: 10.13560/j.cnki.biotech.bull.1985.2019-0691

• 综述与专论 • 上一篇    下一篇

山羊基因组与遗传变异图谱研究进展

李晓凯1, 范一星1, 乔贤1, 张磊1, 王凤红1, 王志英1, 王瑞军1,2,3, 张燕军1,2,3, 刘志红1,2,3, 王志新1, 何利兵4, 李金泉1,2,3, 苏蕊1,2,3, 张家新1   

  1. 1. 内蒙古农业大学动物科学学院,呼和浩特 010018;
    2. 农业部肉羊遗传育种重点实验室,呼和浩特 010018;
    3. 内蒙古自治区山羊遗传育种工程技术研究中心,呼和浩特 010018;
    4. 内蒙古金莱牧业科技有限责任公司,呼和浩特 010018
  • 收稿日期:2019-08-02 出版日期:2020-04-26 发布日期:2020-04-30
  • 作者简介:李晓凯,男,博士研究生,研究方向:绒山羊分子遗传育种;E-mail:lixiaokai1990@126.com
  • 基金资助:
    国家自然科学基金项目(31660639,31860637),国家绒毛用羊现代农业产业技术体系(CARS-39-06),内蒙古自治区研究生教育创新计划资助项目(B20171012901Z),内蒙古农业大学“双一流”学科创新团队建设人才培育项目(NDSC2018-01)

Research Progress of Goat Genome and Genetic Variation Map

LI Xiao-kai1, FAN Yi-xing1, QIAO Xian1, ZHANG Lei1, WANG Feng-hong1, WANG Zhi-ying1, WANG Rui-jun1,2,3, ZHANG Yan-jun1,2,3, LIU Zhi-hong1,2,3, WANG Zhi-xin1, HE Li-bing4, LI Jin-quan1,2,3, SU Rui1,2,3, ZHANG Jia-xin1   

  1. 1. College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018;
    2. Key Laboratory of Mutton Sheep Genetics and Breeding,Ministry of Agriculture,Hohhot 010018;
    3. Engineering Research Center for Goat Genetics and Breeding,Inner Mongolia Autonomous Region,Hohhot 010018;
    4. Inner Mongolia Jinlai Livestock Technology Co.,Ltd,Hohhot 010018
  • Received:2019-08-02 Published:2020-04-26 Online:2020-04-30

摘要: 高通量测序技术和生物信息学的发展极大的促进了山羊分子生物学研究。山羊参考基因组的不断完善以及基因组重测序技术的应用,在全基因组水平上发现了大量的遗传变异信息(SNP、Indel和CNV),丰富了山羊分子群体遗传学研究利用的分子标记。综述了山羊参考基因组组装和全基因组变异图谱的构建及其在山羊上的研究进展,以期为进一步利用分子遗传标记进行山羊的各种性状的遗传基础研究和遗传资源保护利用提供科学依据和参考。

关键词: 山羊, 参考基因组, 遗传变异, 单核苷酸多态性, 插入缺失, 拷贝数变异

Abstract: The development of high-throughput sequencing technology and bioinformatics has greatly promoted the research of goat molecular biology. With the continuous improvement of goat reference genome and the application of whole genome re-sequencing technology,a large number of genetic variation information has been found at the whole genome level(SNP,Indel and CNV),which enriches the available molecular markers used in goat molecular population genetics research. This paper reviews the research and application progress of goat reference genome and whole genome variation map on goat,aiming at providing scientific basis and reference for further genetic basic research and genetic resource conservation and utilization of goat traits by using molecular genetic markers.

Key words: goat, reference genome, genetic variation, single nucleotide polymorphism, insertion and deletion, copy number variation