[1] Kharitonenkov A. FGFs and metabolism[J]. Curr Opin Pharmacol, 2009, 9(6)：805-810.
[2] Kharitonenkov A, Shanafelt AB. Fibroblast growth factor-21 as a therapeutic agent for metabolic diseases[J]. Biodrugs, 2008, 22(1)：37-44.
[3] Nicholes K, Guillet S, Tomlinson E, et al. A mouse model of hepatocellular carcinoma ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice[J]. Am J Pathol, 2002, 160(6)：2295-2307 .
[4] 付宏岐, 李海燕, 庞实锋, 等. 利用转基因番茄表达人成纤维细胞生长因子21(FGF21)[J]. 西北农林科技大学学报：自然科学版[J]. 2011, 39(7)：163-170.
[5] 张谢, 王周光, 李晓霞, 等. 一个新的代谢调节因子——成纤维细胞生长因子21[J]. 药物生物技术, 2011, 18(3)269-272.
[6] Xu J, Lloyd DJ, Hale C, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice[J]. Diabetes, 2009, 58(1)：250-259.
[7] Mashili FL, Austin RL, et al. Direct effects of FGF21 on glucose upt-ake in human skeletal muscle：implications for type 2 diabetes and obesity[J]. Diabetes Metab Res Rev, 2011, 27(3)：286-297.
[8] Kharitonenkov A, Wroblewski VJ, Koester A, et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor 21[J]. Endocrinology, 2007, 148(2)：774-781.
[9] Wang H, Xiao Y, Fu L, et al. High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli[J]. BMC Biotechnololy, 2010, 10：14.
[10] Seo JA, Kim NH. Fibroblast growth factor 21：a novel metabolic regulator[J]. Diabetes Metab, 2012, 36：26-28.
[11] Chen WW, Li L, et al. Circulating FGF-21 levels in normal subjects and in newly diagnosed patients with Type 2 diabetes mellitus[J]. Exp Clin Endocrinol Diabetes, 2008, 116：65-68.
[12] Zhang X, Yeung DC, Karpisek M, et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans[J]. Diabetes, 2008, 57：1246-1253.
[13] 李思明, 沙长青, 高扬, 等. 中国东北地区妊娠期糖尿病妇女与妊娠健康妇女血清成纤维细胞生长因子(FGF21)表达量差异性研究[J]. 黑龙江科学, 2013, 4(8)：23-25.
[14] Chen C, Cheung BM, Tso AW, et al. High plasma level of fibroblast growth factor 21 is an independent predictor of type 2 diabetes：A 5. 4-year population-based prospective study in Chinese subjects[J]. Diabetes Care, 2011, 34(9)：2113-2115.
[15] Nishimura T, Nakatake Y, Konishi M, et al. Identification of a novel FGF, FGF-21, preferentially expressed in the liver[J]. Biochim Biophys Acta, 2000, 1492(1)：203-206.
[16] Yasuhiro I, Holly AB, Noriyuki O, et al. FGF21 is an Akt-regulated myokine[J]. FEBS Letters, 2008, 58(2)：3805-3810.
[17] Wang H, Qiang L, Farmer SR, et al. Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes[J]. Mol Cell Biol, 2008, 28(1)：188-200.
[18] Wente W, Alexander M, Efanov, et al. Fibroblast growth factor-21 improves pancreatic β-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and akt signaling Path-ways[J]. American Diabetes Association, 2006, 55(9)：2470-2478.
[19] 柳景华, 吕昀, 等. 成纤维细胞生长因子21基因在心脏中表达的研究[J]. 心肺血管病杂志, 2009, 28(6)：415-418.
[20] Zhao Y, Dunbar JD, Kharitonenkov A. FGF21 as a therapeutic reagent[J]. Adv Exp Biol, 2012, 728：214-228. |
