淡紫拟青霉次级代谢产物的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2018-0049

摘要/Abstract

摘要： 淡紫拟青霉是子囊菌门、肉座菌目、蛇形虫草科、Purpureocillium属的一种丝状真菌。它是一种广谱性很强的生防菌,不仅对植物寄生线虫、蚜虫、红蜘蛛、温室粉虱和切叶蚁等有很好的防治作用,而且对多种植物病原真菌、细菌乃至病毒也有抑制作用。淡紫拟青霉分泌的几丁质酶与丝氨酸蛋白酶能够降解线虫表皮的蛋白质和几丁质组成成分,利于侵入并破坏细胞成分;也能内生于植物,产生效应物对其它真菌产生拮抗作用;也能定殖于植物根际,产生次级代谢产物,对真菌、线虫等产生抑杀作用。目前对淡紫拟青霉次级代谢产物的研究主要有非核糖体肽类、生物碱及聚酮化合物等的合成调控、活性作用和分子结构确定。淡紫拟青霉所产的非核糖体肽类化合物有白灰制菌素A和B,生物碱有拟青霉酰胺,聚酮化合物有Acremoxanthone C和Acremonidin A。综述了淡紫拟青霉次级代谢产物的研究进展,讨论了淡紫拟青霉次级代谢产物的研究意义,最后展望了淡紫拟青霉的研究前景,以期为相关研究者了解淡紫拟青霉提供参考。

关键词: 淡紫拟青霉, 次级代谢产物, 白灰制菌素, Acremoxanthone C, 拟青霉酰胺

Abstract: Purpureocillium lilacinum is a filamentous fungus belonging to Purpureocillium of Ophiocordycipitaceae of Hypocreales of Ascomycota. It is a kind of broad-spectrum bio-control fungi,and it not only has good control effects on plant parasitic nematodes,aphids,red spiders,green house whitefly,leaf-cutting ants,etc.,but also has antagonistic effects on a variety of plant pathogenic fungi,bacteria and even viruses. P. lilacinum can secrete chitinase and serine proteases,thereby degrading the proteins and chitin constituents of the nematode epidermis,facilitating invasion and destruction of cellular components. P. lilacinum may also be endogenous to plants,producing effectors that antagonize other fungi. P. lilacinum may colonize the rhizosphere of plants,producing secondary metabolites that can inhibit fungi and nematodes. At present,the studies on the secondary metabolites of P. lilacinum mainly include the synthesis regulation,activity and molecular structure determination of non-ribosomal peptides,alkaloids,and polyketides. The non-ribosomal peptide compounds produced by P. lilacinum are leucinostatin A and B,alkaloid is paecilomide,and polyketide compounds are Acremoxanthone C and Acremonidin A. This paper mainly reviewed the research progress on the secondary metabolites from P. lilacinum,discussed research significance of secondary metabolites from P. lilacinum,and finally,prospected the study foreground of P. lilacinum,so as to provide a reference for the relevant researchers.

Key words: Purpureocillium lilacinum, secondary metabolite, leucinostatin, Acremoxanthone C, paecilomide

郝泽婷, 郝晓慧, 阎婧, 谢丙炎, 梁丽琴. 淡紫拟青霉次级代谢产物的研究进展[J]. 生物技术通报, 2018, 34(10): 11-17.

HAO Ze-ting, HAO Xiao-hui, YAN Jing, XIE Bing-yan, LIANG Li-qin. Research Progress on the Secondary Metabolite of Purpureocillium lilacinum[J]. Biotechnology Bulletin, 2018, 34(10): 11-17.

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