脂联素及其受体在哺乳动物中的研究进展与展望

doi:10.13560/j.cnki.biotech.bull.1985.2019-0829

摘要/Abstract

摘要： 脂肪组织分泌的一种内源性细胞因子—脂联素,在其受体的作用下,参与机体的能量平衡、葡糖糖代谢、脂肪酸氧化、抗炎、胰岛素拮抗等方面的调节,发挥着重要的生物学功效。就脂联素及其受体的结构特征、表达调控及多态性,针对提高哺乳动物的生长与繁殖性能,降低哺乳动物体内的脂肪沉积等问题作一综述。

关键词: 脂联素, 脂联素受体, 表达调控, 多态性

Abstract: As an endogenous cytokine secreted from adipose tissue,adiponectin plays an importantly biological role in regulating energy homeostasis,glucose metabolism,fatty acid oxidation,anti-inflammatory,and development of insulin resistance via its receptor’s effects. In order to provide some theory basis and new ideas for molecular breeding in mammal. This review focuses on the structural characteristics,expression regulation and polymorphism of adiponectin and its receptors,on how to improve mammal’s growth and reproductive performance,and on how to reduce fat deposition in mammals and so on.

Key words: adiponectin, adiponectin receptor, expression regulation, polymorphism

张德荣, 马晓霞, 李羽翡, 赵永清, 霍生东, 马忠仁, 柏家林. 脂联素及其受体在哺乳动物中的研究进展与展望[J]. 生物技术通报, 2020, 36(6): 236-244.

ZHANG De-rong, MA Xiao-xia, LI Yu-fei, ZHAO Yong-qing, HUO Sheng-dong, MA Zhong-ren, BAI Jia-lin. Research Progress and Prospects of Adiponectin and Its Receptor in Mammal[J]. Biotechnology Bulletin, 2020, 36(6): 236-244.

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