海洋动物Toll 样受体的研究进展

摘要/Abstract

摘要： Toll 样受体（Toll-like receptor，TLR）是先天性免疫系统中古老的模式识别受体家族，一直都是免疫学家研究的焦点。从最古老的后生动物——海绵到高等的海洋脊椎动物——硬骨鱼中都有TLR 存在。阐述处于不同进化地位海洋动物的TLR 及其信号通路分子，TLR 基因结构域混编和多态性机制，有助于揭示脊椎动物TLR 的起源和预防海洋经济动物病害。

关键词: TLR , 海洋动物 , 信号通路 , 结构域混编 , 多态性

Abstract: Toll-like receptors are a family of the primitive pattern recognition receptors in innate immunity system, which attract theinterest of immunologists all the time. Animals from the most ancient metazoan phylum porifera to bony fish are considered to possess TLR genes.In this paper, we collect the latest data about TLR and signaling pathway molecules from different marine phyla, the mechanisms of domainshuffling and polymorphism of TLR, which will be useful for exploring the origin of vertebrate TLR and prevent marine animals from diseases.

Key words: TLR , Marine animal , Signaling pathway , Domain shuffling , Polymorphism

孙红娟, 周遵春, 崔军, 王秀利. 海洋动物Toll 样受体的研究进展[J]. 生物技术通报, 2013, 0(1): 41-48.

Sun Hongjuan, Zhou Zunchun, Cui Jun, Wang Xiuli. Insights into Toll-like Receptor from Marine Animals[J]. Biotechnology Bulletin, 2013, 0(1): 41-48.

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