造血微环境的细胞和分子机理

摘要/Abstract

摘要： 造血干细胞（hematopoietic stem cell，HSC）是造血前体细胞，存在于特定的三维空间结构中，即通常所说的造血微环境或造血干细胞壁龛（niche）。造血微环境控制着HSC的自我更新和分化。目前关于造血微环境的结构、细胞组成和分子机理还不太清楚，阐明其中的细胞和分子机制是将来更好地将HSC用于临床的关键所在。综述造血微环境的细胞组成以及HSC和微环境之间的信号通路的研究进展。

关键词: 造血干细胞, 造血微环境, 壁龛, 信号通路

Abstract: Hematopoietic stem cells（HSCs）are thought to reside in specific three-dimensional spatial structure, know as the hematopoietic microenviroment or niche. Studies on stem cells have shown that stem cell function is controlled by intrinsic genetic programs within the stem cell and by extracellular cues from the niche. The niche provides the extrinsic molecular mechanisms that control stem cell maintenance, self-renewal and differentiation. Nevertheless, the structure as well as cellular and molecular basis for niche activity, have long remained a ‘black box’. Elucidating the mechanisms holds many promises for future clinical applications and regenerative medicine. We reviewed the remarkable progress recently made in characterizing the composition of the niche and the molecular crosstalk between HSCs and the cellular constituents of the niche.

Key words: Hematopoietic stem cell, Hematopoietic microenviroment, Niche, Signaling

刘佳佳, 张亦婷, 彭航, 刘鹏霞. 造血微环境的细胞和分子机理[J]. 生物技术通报, 2013, 0(8): 17-22.

Liu Jiajia, Zhang Yiting, Peng Hang, Liu Pengxia. Advances in Cellular and Molecular Basis of Hematopoietic Stem Cell Niche[J]. Biotechnology Bulletin, 2013, 0(8): 17-22.

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