转录因子HIF-1α及其信号通路在疾病发生中的作用研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2016.08.002

摘要/Abstract

摘要：

缺氧诱导因子-1α（hypoxia inducible factor-1α,HIF-1α）是缺氧条件下广泛存在于哺乳动物和人体内的一种转录因子,是应答缺氧应激的关键因子。HIF-1α是缺氧诱导因子-1（hypoxia inducible factor-1,HIF-1）的一个亚单位,受缺氧调控并调节HIF-1的活性。在缺氧条件下,HIF-1α转移到细胞核内结合HIF-1β形成有活性的HIF-1,通过与靶基因上的缺氧反应元件结合调节多种基因的转录。HIF-1α可以与上下游多种蛋白组成不同的信号通路,介导低氧信号,调控细胞产生一系列对缺氧的代偿反应,在机体的生长发育及生理和病理过程中发挥重要作用,是生物医学研究的一个焦点。对转录因子HIF-1α及其信号通路在疾病发生中的作用进行了综述,介绍了HIF-1α在动物生长发育、炎症和肿瘤中的研究概况,并进行了展望,以便更好地应用于生物医学。

关键词: 缺氧诱导因子-1&#x003b1, 信号通路, 疾病

Abstract:

Hypoxia inducible factor-1α（HIF-1α）is a transcription factor under hypoxia condition,which widely exists in mammals and human body. It is a key factor responding to hypoxic stress. HIF-1α is a subunit of hypoxia inducible factor-1（HIF-1）and considered as the master transcriptional regulator of cellular and developmental response to hypoxia,and regulates the activity of HIF-1. During hypoxia,HIF-1α translocates from the cytoplasm to the nucleus,where it dimerizes with HIF-1β and the transcriptionally active HIF-1 complex is formed;the activated HIF complex then associates with HREs in the regulatory regions of target genes to induce gene expression. Forming varied signal pathways with multiple proteins in up- and down- streams,HIF-1α mediates hypoxic signals,then regulates a series of hypoxic compensatory response of cell,which plays a crucial role in body growth,physiological and pathological processes,thus it is a focus of biomedical research. We reviewed the role of transcription factors HIF-1α and its signaling pathway in the occurrence of disease , and introduced to the relationship among HIF-1α and growth, development, inflammation and tumor , then carryed out the prospect, in order to better be used in biomedical.

Key words: hypoxia inducible factor-1&#x003b1, signal pathway, disease

杨梦思,周娜,王志钢,郝慧芳. 转录因子HIF-1α及其信号通路在疾病发生中的作用研究进展[J]. 生物技术通报, 2016, 32(8): 8-13.

YANG Meng-si, ZHOU Na, WANG Zhi-gang,HAO Hui-fang. Research Progress on the Role of Transcription Factor HIF-1α and Its Signal Pathway in the Pathogenesis[J]. Biotechnology Bulletin, 2016, 32(8): 8-13.

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