miR-143在脂肪细胞分化和脂类代谢中的作用

生物技术通报 ›› 2014, Vol. 0 ›› Issue (9): 34-38.

miR-143在脂肪细胞分化和脂类代谢中的作用

李静¹,黄英¹,黄丽梅²,杨明华¹,李琦华¹,贾俊静¹,赵素梅¹

1. 云南农业大学云南省动物营养与饲料重点实验室，昆明 650201;
2. 云南农业大学党委宣传部，昆明 650201

收稿日期:2014-01-21 出版日期:2014-09-15 发布日期:2014-09-07
作者简介:李静，女，硕士研究生，研究方向：分子营养与代谢调控；E-mail：lijing1803@163.com
基金资助:
现代农业产业技术体系建设专项资金（CARS-24），国家公益性行业（农业）科研专项经费项目（201303080）

The Role of miR-143 in the Adipocyte Differentiation and Lipid Metabolism

Li Jing¹, Huang Ying¹, Huang Limei², Yang Minghua¹, Li Qihua¹, Jia Junjing¹, Zhao Sumei¹

1. Yunnan Key Laboratory of Animal Nutrition and Feed Science，Yunnan Agricultural University，Kunming 650201;
2. Office of Party Publicity of Yunnan Agricultural University，Kunming 650201

Received:2014-01-21 Published:2014-09-15 Online:2014-09-07

摘要/Abstract

摘要： miR-143是内源性非编码的RNA，在细胞的分化、发育、增殖、脂肪代谢及疾病产生等许多生物学过程中具有重要作用。miR-143与脂类代谢密切相关，主要通过与靶基因的相互作用，影响脂肪的分化，甘油三酯的合成等。针对miR-143合成、预测的靶基因以及靶基因的调控机制方面进行综述，阐述miR-143在脂肪代谢中的作用，以便为相关疾病的诊断、治疗方面提供新思路。

关键词: 微小RNA, miR-143, 靶基因, 脂类代谢

Abstract: miR-143, discovered in recent years, is a non-coding RNA derived within a class, which plays an important role in many biological processes including cell differentiation, growth, proliferation, fat metabolism, disease and so on. miR-143 is closely related to the adipocyte differentiation and lipid metabolism, which could regulate the differentiation of adipocytes, synthetics of triglycerides primarily by the interaction with the target gene. The synthesis of miR-143, the interaction between miR-143 and the target genes to regulate adipocyte differentiation and lipid metabolism, in order to provide new ideas to the diagnosis and treatment for the obesity disease were reviewed.

Key words: microRNA miR-143 , Target gene , Lipid metabolism

李静,黄英,黄丽梅,杨明华,李琦华,贾俊静,赵素梅. miR-143在脂肪细胞分化和脂类代谢中的作用[J]. 生物技术通报, 2014, 0(9): 34-38.

Li Jing, Huang Ying, Huang Limei, Yang Minghua, Li Qihua, Jia Junjing, Zhao Sumei. The Role of miR-143 in the Adipocyte Differentiation and Lipid Metabolism[J]. Biotechnology Bulletin, 2014, 0(9): 34-38.

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