紫杉醇生物合成研究历史、现状及展望

doi:10.13560/j.cnki.biotech.bull.1985.2015.03.004

摘要/Abstract

摘要： 紫杉醇是从红豆杉中分离出来的一种二萜类化合物，是目前临床上使用最广泛的抗癌药物之一。回顾了紫杉醇生物合成的研究历史，主要包括参与红豆杉紫杉醇生物合成的结构基因、调控基因、红豆杉代谢组、内生真菌紫杉醇生物合成研究历史以及国际上紫杉醇生物合成专利情况等。介绍了近年来红豆杉和内生真菌紫杉醇生物合成研究的现状。最后探讨了本领域未来的研究方向并对其前景进行展望。

关键词: 紫杉醇, 生物合成, 现状, 前景

Abstract: Taxol is a diterpene isolated from Taxus. It is one of the most widely used compounds in the treatment of lung, ovarian and breast cancer. In this paper, the history of taxol biosynthesis research, its current status and the present research progress are reviewed. The future directions as well as the prospects of taxol biosynthesis research are also discussed.

Key words: taxol, biosynthesis research, current status, the prospects

邱德有,张彬,杨艳芳,邵芬娟,滕文静. 紫杉醇生物合成研究历史、现状及展望[J]. 生物技术通报, 2015, 31(4): 56-64.

Qiu Deyou, Zhang Bin, Yang Yanfang, Shao Fenjuan, Teng Wenjing,. History, Current Status and the Prospects of Taxol Biosynthesis Research[J]. Biotechnology Bulletin, 2015, 31(4): 56-64.

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