海绵共附生真菌多样性及其次级代谢产物的研究进展

生物技术通报 ›› 2014, Vol. 0 ›› Issue (4): 36-42.

海绵共附生真菌多样性及其次级代谢产物的研究进展

宋恺^1，2，3, 胡洁³, 林文翰³, 季宇彬^1，2^，3

(1. 哈尔滨商业大学生命科学与环境科学研究中心，哈尔滨 150076；
2. 国家教育部抗肿瘤天然药物工程研究中心，哈尔滨 150076；
3. 北京大学天然药物及仿生药物国家重点实验室，北京 100191)

收稿日期:2013-09-29 出版日期:2014-04-29 发布日期:2014-04-29
作者简介:宋恺，男，硕士研究生，研究方向：海洋天然产物生物合成；E-mail：unochris1314@163.com
基金资助:
国家“863”计划项目(2011AA090701)

Studies on Diversity of Sponges-associated Fungi and Their Secondary Metabolites

Song Kai^1，2，3, Hu Jie³, Lin Wenhan³, Ji Yubin^1，2，3,

(1. Research Center on Life Sciences and Environmental Sciences，Harbin University o f Commerce，Harbin 150076；
2. Engineering Research Center of Natural Anticancer Drugs，Ministry of Education，Harbin 150076；
3. State Key Laboratory of Natural and Biommietic Drugs，Peking University, Beijing 100191)

Received:2013-09-29 Published:2014-04-29 Online:2014-04-29

摘要/Abstract

摘要： 海绵由于其独特的生理结构、进食方式使其体内部聚集了大量的微生物，这些微生物产生了多种结构新颖的生物活性物质，因此海绵及其共附生微生物的研究成为了海洋药物研发的热点。就海绵中共附生真菌的分布情况，新技术的应用及其生物次级代谢产物的生物活性展开综述。

关键词: 海绵, 共附生真菌, 次级代谢产物, 化学防御, 生物活性

Abstract: Because of the unique physiological structure and digest system, marine sponges enrich large numbers of microorganisms. Lots of novel bioactive compounds were isolated and identified from sponges-associated fungi, which is highlight in marine drug discovery. The development on the distribution of fungi, the application of new technique, novel bioactive secondary metabolites and biological activities were reviewed.

Key words: Sponge, Symbiotic-fungi, Secondary metabolites, Chemical defense, Bioactivity

宋恺, 胡洁, 林文翰, 季宇彬. 海绵共附生真菌多样性及其次级代谢产物的研究进展[J]. 生物技术通报, 2014, 0(4): 36-42.

Song Kai, Hu Jie, Lin Wenhan, Ji Yubin,. Studies on Diversity of Sponges-associated Fungi and Their Secondary Metabolites[J]. Biotechnology Bulletin, 2014, 0(4): 36-42.

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