磷脂酶C基因家族研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2014.12.006

摘要/Abstract

摘要： 磷脂酶 C(Phospholipase C，PLC)基因是磷脂酶基因家族中的一个成员，它能够水解磷脂酰肌醇 4，5-二磷酸生成两个重要的信使分子肌醇三磷酸和二酰甘油。在动物中磷脂酶 C 基因可以通过调节胞内钙离子的释放以及激活蛋白激酶 C 来起作用，而植物中磷脂酶 C 可以参与植物对生物及非生物胁迫的调节，但其作用的具体方式仍不清楚。综述了磷脂酶 C 基因的研究进展，主要包括基因的分类、结构以及其在不同逆境信号转导中的作用方式。

关键词: PLC, 基因, 肌醇三磷酸, 二酰甘油, 结构, 信号转导

Abstract: Phospholipase C(PLC)is a key member from phospholipase family, it cleaves phosphatidylinositol 4, 5-bisphosphate(PIP2) into diacylglycerol(DAG)and inositol 1, 4, 5-trisphosphate(IP3). In animals, PLCs are recognized as key components of signals through specific targets, such as protein kinase C or Ca²⁺-dependentsignaling networks. In plants, PLCs were characterized to regulate several abiotic and biotic stresses, but the mechanism of it are still unknown. In this review, we focused on the classification, structure, and the functions in different signal transduction.

Key words: PLC gene, Inositol trisphosphate, Diacylglycerol, Structure, Signal transduction

王法微 ,王骐3 ,邓宇, 董金晔 ,王南 ,李晓薇 ,李海燕. 磷脂酶C基因家族研究进展[J]. 生物技术通报, 2014, 0(12): 33-39.

Wang Fawei,Wang Qi,Deng Yu,Dong Jinye,Wan Nan, Li Xiaowei, Li Haiyan. Advance in the Research of Phospholipase C Gene Family[J]. Biotechnology Bulletin, 2014, 0(12): 33-39.

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