植物WUSCHEL-related homeobox（WOX）家族研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2015.05.002

摘要/Abstract

摘要： WUSCHEL相关的同源异型盒（WUSCHEL-related homeobox，WOX）转录因子家族，在植物发育的众多阶段（茎和根顶端分生区的建成、侧生器官的发育、花器官的形成和胚的发育），尤其是在细胞增殖和分化较为旺盛的区域发挥重要的调控作用，即促进细胞的增殖或抑制细胞的分化。就WOX同源异型盒转录因子家族的系统进化分析、WOX家族成员的分子特征、WOX基因的生物学功能及其作用机制进行综述，并对本领域未来的发展方向作出展望。

关键词: 同源异型盒转录因子, WOX家族, 植物

Abstract: WUSCHEL-related homeobox（WOX）transcription factor, family members are essential in the many stages of plant development（for examples, stem-cell maintenance in shoot and root apical meristem, lateral organ development, floral organ formation and embryonic patterning）by promoting cell proliferation or preventing cell differentiation. We outline the phylogenetic analysis, the molecular characteristics, biological functions and the mechanism of action of WOX gene family members. We also provide prospective vision in this field.

Key words: homeobox transcription factor, WOX protein family, plant

高丽, 孙祎敏, 邵铁梅, 孔卫娜, 崔润丽, 卢楠, 仵陶. 植物WUSCHEL-related homeobox（WOX）家族研究进展[J]. 生物技术通报, 2015, 31(5): 7-12.

Gao Li, Sun Yimin, Shao Tiemei, Kong Weina, Cui Runli, Lu Nan, Wu Tao. Studies on WUSCHEL-related Homeobox（WOX）Protein Family[J]. Biotechnology Bulletin, 2015, 31(5): 7-12.

参考文献

[1] Gehring WJ, Qian YQ, Billeter M, et al. Homeodomain-DNA recognition[J]. Cell, 1994, 78（2）：211-223.
[2] Gehring WJ. Exploring the homeobox[J]. Gene, 1993, 135（1-2）：215-221.
[3] Yadav RK, Reddy GV. WUSCHEL protein movement and stem cell homeostasis[J]. Plant Signal Behav, 2012, 7（5）：592-594.
[4] Stahl Y, Wink RH, Ingram GC, et al. A signaling module controlling the stem cell niche in Arabidopsis root meristems[J]. Curr Biol, 2009, 19（11）：909-914.
[5] Shimizu R, Ji J, Kelsey E, et al. Tissue specificity and evolution of meristematic WOX3 function[J]. Plant Physiol, 2009, 149（2）：841-850.
[6] Ueda M, Zhang Z, Laux T. Transcriptional activation of Arabidopsis axis patterning genes WOX8/9 links zygote polarity to embryo develo-pment[J]. Dev Cell, 2011, 20（2）：264-270.
[7] Lian GB, Ding ZW, Wang Q, et al. Origins and evolution of WUSCHEL-related homeobox protein family in plant kingdom[J]. Scientific World Journal, 2014, ID：534140.
[8] Haecker A, Gross-Hardt R, Geiges B, et al. Expression dynamics of WOX genes mark cell fate decisions during early embryonic patter-ning in Arabidopsis thaliana[J]. Development, 2004, 131（3）：657-668.
[9] Ikeda M, Mitsuda N, Ohme-Takagi M. Arabidopsis WUSCHEL is a bifunctional transcription factor that acts as a repressor in stem cell regulation and as a activator in floral patterning[J]. Plant Cell, 2009, 21（11）：3493-3505.
[10] Paponov IA, Teale W, Lang D, et al. The evolution of nuclear auxin signaling[J]. BMC Evol Biol, 2009, 9：126.
[11] Kieffer M, Stern Y, Cook H, et al. Analysis of the transcription factor WUSCHEL and its functional homologue in Antirrhinum reveals a potential mechanism for their roles in meristem mainte-nance[J]. Plant Cell, 2006, 18（3）：560-573.
[12] Nardmann J, Werr W. The shoot stem cell niche in angiosperms：expression patterns of WUS orthologues in rice and maize imply major modifications in the course of mono-and dicot evolution[J]. Mol Biol Evol, 2006, 23（12）：2492-2504.
[13] Gross-Hardt R, Lenhard M, Laux T. WUSCHEL signaling functions in interregional communication during Arabidopsis ovule development[J]. Genes Dev, 2002, 16（9）：1129-1138.
[14] Deyhle F, Sarkar AK, Tucker EJ, et al. WUSCHEL regulates cell differentiation during anther development[J]. Dev Biol, 2007, 302（1）：154-159.
[15] Vandenbussche M, Horstman A, Zethof J, et al. Differential recrui-tment of WOX transcription factors for lateral development and organ fusion in petunia and Arabidopsis[J]. Plant Cell, 2009, 21（8）：2269-2283.
[16] Tadege M, Lin H, Bedair M, et al. STENOFOLIA regulates blade outgrowth and leaf vascular patterning in Medicago truncatula and Nicotiana sylvestris[J]. Plant Cell, 2011, 23（6）：2125-2142.
[17] Lin H, Niu LF, McHale NA, et al. Evolutionarily conserved repressive activity of WOX proteins mediates leaf blade outgrowth and floral organ development in plants[J]. Proc Natl Acad Sci USA, 2013, 110（1）：366-371.
[18] Nakata M, Matsumoto N, Tsugeki R, et al. Roles of the middle domain-specific WUSCHEL-RELATED HOMEOBOX genes in early development in Arabidopsis[J]. Plant Cell, 2012, 24：519-535.
[19] Palovaara J, Hakman I. WOX2 and polar auxin transport during spruce embryo pattern formation[J]. Plant Signal Behav, 2009, 4（2）：153-155.
[20] Matsumoto N, Okada K. A homeobox gene PRESSED FLOWER regulates lateral axis-dependent development of Arabidopsis flowers[J]. Genes Dev, 2001, 15（24）：3355-3364.
[21] Nardmann J, Werr W, Scanlon MJ. The maize duplicate genes narrow sheath1 and narrow sheath2 encode a conserved homeobox gene function in lateral domain of shoot apical meristems[J]. Development, 2004, 131（12）：2827-2839.
[22] Hirakawa Y, Kondo Y, Fukuda H. TDIF peptide signaling regulates vascular stem cell proliferation via the WOX4 homeobox gene in Arabidopsis[J]. Plant Cell, 2010, 22（8）：2618-2629.
[23] Qiang Y, Wu JB, Han HB, et al. CLE peptides in vascular development[J]. JIntegrativePlantBiol, 2013, 55：389-394.
[24] Zhao S, Jiang QT, Ma J, et al. Characterization and expression analysis of WOX5 genes from wheat and its relatives[J]. Gene, 2014, 537（1）：63-69.
[25] Park SO, Zheng Z, et al. The PRETTY FEW SEEDS2 gene encodes an Arabidopsis homeodomain protein that regulates ovule development[J]. Development, 2005, 132（4）：841-849.
[26] Shimizu R, Ji J, Kelsey E, et al. An Arabidopsis homeodomain transcription factor gene, HOS9, mediates cold tolerance through a CBF-independent pathway[J]. Proc Natl Acad Sci USA, 2004, 101（26）：9873-9878.
[27] Wu X, Chory J, Weigel D. Combinations of WOX activities regulate tissue proliferation during Arabidopsis embryonic development[J]. Dev Biol, 2007, 309（2）：306-316.
[28] Lie C, Kelsom C, Wu X. WOX2 and STIMPY-LIKE/WOX8 promote cotyledon boundary formation in Arabidopsis[J]. Plant J, 2012, 72（4）：674-682.
[29] Wu XL, Dabi T, Weigel D. Requirement of homeobox gene STIM-PY/WOX9 for Arabidopsis meristem growth and maintenance[J]. Curr Biol, 2005, 15（5）：436-440.
[30] Zhao Y, Hu YF, Dai MQ, et al. The WUSCHEL-Related homeobox gene WOX11 is required to activate shoot-borne crown root develo-pment in rice[J]. Plant Cell, 2009, 21（3）：736-748.
[31] Deveaux Y, Toffano-Nioche C, Claisse G, et al. Genes of the most conserved WOX clade in plants affect root and flower development in Arabidopsis[J]. BMC Evol Biol, 2008, 8：291.
[32] van der Graaff E, Laux T, Rensing SA. The WUS homeobox-contai-ning（WOX）protein family[J]. Genome Biol, 2009, 10：248.
[33] Mayer KF, Schoof H, Haecker A, et al. Role of WUSCHEL in regulating stem cell fate in the Arabidopsis shtto meristem[J]. Cell, 1998, 95（6）：805-815.
[34] Dai M, Hu Y, Zhao Y, et al. A WUSCHEL-LIKE HOMEOBOX gene represses a YABBY gene expression required for rice leaf development[J]. Plant Physiol, 2007, 144（1）：380-390.
[35] Schoof H, Lenhard M, Haecker A, et al. The stem cell population of Arabidopsis shoot meristems in maintained by a regulatory loop between the CLAVATA and WUSCHEL genes[J]. Cell, 2000, 100（6）：635-644.
[36] Sarkar AK, Luijten M, Miyashima S, et al. Conserved factors regulate signaling in Arabidopsis thaliana shoot and root stem cell organizers[J]. Nature, 2007, 446（7137）：811-814.
[37] Breuninger H, Rikirsch E, Hermann M, et al. Differential expression of WOX genes mediates apical-basal axis formation in Arabidopsis embryo[J]. Dev Cell, 2008, 14（6）：867-876.
[38] Yadav RK, Perales M, Gruel J, et al. WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex[J]. Genes Dev, 2011, 25（19）：2025-2030.
[39] Chu HW, Liang WQ, Li J, et al. A CLE-WOX signaling module regulates root meristem maintenance and vascular tissue develo-pment in rice[J]. J Exper Botany, 2013, 64：5359-5369.
[40] Etchells JP, Turner SR. The PXY-CLE41 receptor ligand pair defines a multifunctional pathway that controls the rate and orientation of vascular cell division[J]. Development, 2010, 137（5）：767-774.
[41] Long JA, Ohno C, Smith ZR, et al. TOPLESS regulates apical embryonic fate in Arabidopsis[J]. Science, 2006, 312（5779）：1520-1523.
[42] Leibfried A, To JP, Busch W, et al. WUSCHEL controls meristem function by direct regulation of cytokinin-inducible response regulators[J]. Nature, 2005, 438（7071）：1172-1175.