生物合成芳香族氨基酸及其衍生物的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2017.01.003

摘要/Abstract

摘要： 现代生物化工主要以廉价可再生资源为底物生产高附加值的精细化学品、大宗化学品、药品及营养品。合成生物学研究是生物化工领域的重要发展方向和支撑体系之一，是在功能基因组学、计算生物学和系统生物学等基础上，将工程化理念应用在生物学中，定向创造新型生物产品和生物过程整体优化的新的研究方向。合成生物学发展十几年以来，创造出了很多强有力的工具被应用于微生物、植物及动物的研究。以微生物生产芳香族氨基酸及其衍生物为主要内容，系统的综述合成生物学在以微生物生产高附加值产物方面的研究进展。

关键词: 合成生物学, 芳香族氨基酸, 黄酮类, 有机酸, 天然产物

Abstract: Bioengineering has been used to produce various of value-added products including fine chemicals,bulk chemicals,pharmaceuticals and nutraceuticals using sustainable materials. Synthetic biology is the foundation of bioengineering which combined functional genomics,computational biology with system biology to createnovel products and optimize bioprocess. In the past decades,many powerful tools developed from synthetic biology has been used in microorganisms,plants and animals. In this review,we summarize the synthesis of aromatic amino acids and its derivatives in microorganisms and review the recent advances in bio-production of value-added chemicals using synthetic biology.

Key words: synthetic biology, aromaticacids, flavonoids, organicacids, naturalproducts

申晓林，袁其朋. 生物合成芳香族氨基酸及其衍生物的研究进展[J]. 生物技术通报, 2017, 33(1): 24-34.

SHEN Xiao-lin, YUAN Qi-peng. Research Advance on Biosynthesis of Aromatic Amino Acids and Their Derivatives[J]. Biotechnology Bulletin, 2017, 33(1): 24-34.

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