微生物合成腺苷蛋氨酸的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2017.01.010

摘要/Abstract

摘要： 腺苷蛋氨酸（SAM）是一种存在于所有细胞中的重要代谢产物，对肝病、抑郁症等疾病具有良好疗效，并且无任何副作用，市场需求巨大。目前，国内外学者对SAM的生物合成进行了广泛的研究，一方面在传统发酵法工业化生产SAM的基础上进一步改进发酵策略;另一方面通过代谢工程优化宿主菌代谢网络或者利用基因电路等巧妙筛选方法来进行理性化育种。综述了微生物高效生产SAM的研究进展，讨论了微生物高效生产SAM的意义及存在的问题，旨为提高SAM工业化生产效率提供指导性意义。

关键词: 腺苷蛋氨酸, 酵母, 基因电路, 发酵, 代谢改造

Abstract: S-adenosyl-L-methionine（SAM）as an important metabolite exists in all cell types of living organisms,presents promising effects on liver diseases and depressive syndromes without any side effects,thus,it is greatly demanded in medical market. Recently,broad studies on biosynthesis of SAM have been conducted by scholars in the world. On the one hand,fermentation strategies based on traditionally producing SAM were further improved;on the other hand,different rational breeding programs were developed,such as fine tuning host’s metabolic network or screening strains by synthetic gene circuit. In this paper,progress in the research of S-adenosyl-L-methionine production is summarized,and the significances and issues while efficiently producing SAM by microorganism are discussed,aiming at providing the guides for improving SAM productivity at an industrial scale.

Key words: S-adenosyl-L-methionine, yeast, synthetic gene circuit, fermentation, metabolic engineering

赵伟军，黄磊，徐志南. 微生物合成腺苷蛋氨酸的研究进展[J]. 生物技术通报, 2017, 33(1): 99-105.

ZHAO Wei-jun, HUANG Lei, XU Zhi-nan. Research Progress on the Synthesis of S-adenosyl-L-methionine in Microorganism[J]. Biotechnology Bulletin, 2017, 33(1): 99-105.

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