植物F-box基因家族的研究进展

doi:10.13560/j.cnki.biotech.bull.1985.2017-0636

摘要/Abstract

摘要： F-box基因家族是植物中最大的基因家族之一,由于其数量巨多,根据其蛋白C末端结构域的不同被分为不同的亚家族。F-box基因编码的蛋白能够调节多种多样的生命活动,如延缓植物衰老、调控植物开花以及响应生物胁迫、干旱和盐等逆境胁迫。近年来,随着全基因组测序的不断完善,越来越多物种的F-box基因被分析鉴定出来。已经鉴定出功能的F-box基因编码的蛋白大多能够和结合蛋白Skp1、骨架蛋白Cullin 1及Rbx1形成SCF复合体,进而参与泛素-蛋白酶途径（UPP）而发挥作用;少部分F-box蛋白以非SCF复合体形式发挥作用。泛素-蛋白酶途径（UPP）是机体重要的调节机制之一,大多数细胞内蛋白都是经过这一途径降解。主要对其蛋白结构,作用途径以及生物学功能进行概述,探讨F-box基因参与的生命活动,旨为F-box的深入研究奠定基础。

关键词: F-box基因, 逆境胁迫, SCF复合体, 泛素-蛋白酶途径（UPP）

Abstract: The F-box gene family is one of the largest gene families in plants. According to its protein C-terminal domain,F-box genes are divided into different subfamilies,for its number is large. Proteins encoded by F-box gene can regulate a variety of life activities,such as delaying plant senescence,regulating plant flowering and response to biological stress,drought and salt stress. In recent years,with the improvement of whole genome sequencing,more and more F-box genes of different species were identified. Most of the F-box proteins encoded by the F-box gene can form SCF complexes by binding with proteins Skp1,the skeletal proteins Cullin 1 and Rbx1,which then participates in the ubiquitin-protease pathway（UPP）. A small number of F-box proteins play a role in non-SCF complexes. UPP is one of the key regulatory mechanisms,and through which the most of the intracellular proteins are degraded. This review mainly summarizes the protein structures,function pathways and biological functions of F-box gene,and explores the life activities involved by F-box gene,aiming at laying the foundation for intensively investigating F-box.

Key words: F-box gene, stress, SCF complex, ubiquitin-protease pathway（UPP）

许克恒, 张云彤, 张莹, 王彬, 王法微, 李海燕. 植物F-box基因家族的研究进展[J]. 生物技术通报, 2018, 34(1): 26-32.

XU Ke-heng, ZHANG Yun-tong, ZHANG Ying, WANG Bin, WANG Fa-wei, LI Hai-yan. Research Advances on the F-box Gene Family in Plants[J]. Biotechnology Bulletin, 2018, 34(1): 26-32.

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