Advance in Antitumor Mechanism of Bioactive Compounds in Edible Mushrooms

doi:10.13560/j.cnki.biotech.bull.1985.2015.04.005

Abstract

Abstract: Edible mushrooms have been globally consumed for centuries to promote human health, prevent and treat human diseases. In different types of edible mushrooms, there are distinct bioactive compounds, mainly consisted of polysaccharide, protein, terpenoids, alkaloids and others substances. They possess many medicinal effects such as anti-cancer, anti-cardiovascular diseases, and anti-diabetes, etc. Mushroom bioactive constituents have been found to have anti-cancer effects against several major cancer types. It is reported that edible mushrooms exert an anti-cancer effect through regulating the expression level of relevant factors in cell signaling pathway, which leads to inhibition of cell proliferation and induction of cellular apoptosis. These findings may provide theoretical basis for utilizing edible mushrooms as potential natural and non-toxic antitumor agents. This paper provided a brief review on the research progress in antitumor mechanism of different bioactive compounds in edible mushrooms..

Key words: edible mushrooms, bioactive compounds, anti-tumor

Chen Kaixu, Wang Weilan, Liu Jun, Zhang Fuchun, Zheng Xiufen. Advance in Antitumor Mechanism of Bioactive Compounds in Edible Mushrooms[J]. Biotechnology Bulletin, 2015, 31(3): 35-42.

References

[1] Kim SY, Go KC, Song YS, et al. Extract of the mycelium of T. matsu-take inhibits elastase activity and TPA-induced MMP-1 expression in human fibroblasts[J]. Int J Mol Med, 2014, 34(6)：1613-1621.
[2] Costa Orsine JV, Novaes MC, Ramirez Asquieri E, et al. Determina-tion of chemical antioxidants and phenolic compounds in the Brazi-lian Mushroom Agaricus sylvaticus[J]. West Indian Med J, 2014, 63(2)：146-150.
[3] Schwartz B, Hadar Y. Possible mechanisms of action of mushroom-derived glucans on inflammatory bowel disease and associated cancer[J]. Ann Transl Med, 2014, 2(2)：19.
[4] Ivanova TS, Krupodorova TA, Barshteyn VY, et al. Anticancer substances of mushroom origin[J]. Exp Oncol, 2014, 36(2)：58-66.
[5] Liao SF, Liang CH, Ho MY, et al. Immunizationof fucose-containing polysaccharides from Reishimushroominduces antibodies to tumor-associated Globo H-series epitopes[J]. Proc Natl Acad Sci USA, 2013, 110(34)：13809-13814.
[6] Patel S, Goyal A. Recent developments in mushrooms as anti-cancer therapeutics：a review[J]. Biotech, 2012, 2(2)：1-15.
[7] Facchini JM, Alves EP, Aguilera C, et al. Antitumor activity ofPleurotus ostreatuspolysaccharide fractions on Ehrlich tumor and Sarcoma 180[J]. Int J Biol Macromol, 2014, 68(1)：72-77.
[8] Tong H, Xia F, Feng K, et al. Structural characterization and in vitro antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus[J]. Bioresour Technol, 2009, 100(4)：1682-1686.
[9] Wong SM, Wong KK, Chiu LCM, et al. Non-starch polysaccharides from different developmental stages of Pleurotus tuberregium inhibited the growth of human acute promyelocytic leukemia HL-60 cells by cell-cycle arrest and/or apoptotic induction[J]. Carbohydr Polym, 2007, 68(2)：206-217.
[10] Wu B, Cui J, Zhang C, et al. A polysaccharide from Agaricus blazei inhibits proliferation and promotes apoptosis of osteosarcoma cells[J]. International Journal of Biological Macromolecules, 2012, 50(4)：1116-1120.
[11] Chen J, Seviour R. Medicinal importance of fungal β-(1→3)(1→6)-glucans[J]. Mycol Res, 2007, 111(6)：635-652.
[12] Shi BJ, Nie XH, Chen LZ, et al. Anticancer activities of a chemically sulphated polysaccharide obtained from Grifola frondosa and itscombination with 5-Fluorouracil against human gastric carcinoma cells[J]. Carbohydr Polym, 2007, 68(4)：687-692.
[13] Masuda Y, Inoue M, Miyata A, et al. Maitake β-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice[J]. Int Immunopharmacol, 2009, 9(5)：620-626.
[14] Julia JV, Johannes PFGH, Song W, et al. Effects of mushroom-derived β-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-jB transactivation in Caco-2 reporter cells：Can effects be explained by structure?[J]. Mol Nutr Food Res, 2010, 54(2)：268-276.
[15] Kim HS, Kim JY, Kang JS, et al. Cordlan polysaccharide isolated from mushroom Cordyceps militaris induces dendritic cell maturation through toll-like receptor 4 signalings[J]. Food and Chemical Toxicology, 2010, 48(7)：1926-1933.
[16] Liao SF, Liang CH, Ho MY, et al. Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes[J]. PNAS, 2013, 110(34)：13809-13814.
[17] Song FQ, Liu Y, Kong XS, et al. Progress on understanding the anticancer mechanisms of medicinal mushroom：inonotus obliquus[J]. Asian Pac J Cancer Prev, 2013, 14(3)：1571-1578.
[18] Hsieh TC, Wu JM. Cell growth and gene modulatory activities of Yunzhi(Windsor Wunxi)from mushroom Trametes versicolor in androgen-dependent and androgen-insensitive human prostate cancer cells[J]. Int J Oncol, 2001, 18(1)：81-88.
[19] Cui FJ, LiY, Xu YY, et al. Induction of apoptosis in SGC-7901 cells by polysaccharide-peptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801[J]. Toxicology in Vitro, 2007, 21(3)：417-427.
[20] Hsieh TC, Wu JM. Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by the combination of Coriolus versicolor and Ganoderma lucidum[J]. Int J Mol Med, 2013, 32(1)：251-257.
[21] Ng TB, Ngai PHK, Li XX, et al. An agglutinin with mitogenic and antiproliferative activities from the mushroom Flammulina velutipes[J]. Mycologia, 2006：98(2)：167-171.
[22] Chang HH, Hsieh KY, Ye CH, et al. Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity againstmurine hepatocellular carcinoma[J]. International Immunopharmacology, 2010, 10(2)：239-246.
[23] Wu YY, Wang HX, Ng TB. Purification and characterization of a lectin with antiproliferative activity toward cancer cells from the dried fruit bodies of Lactarius flavidulus[J]. Carbohydrate Research, 2011, 346(16)：2576-2581.
[24] Zou YJ, Wang HX, Ng TB, et al. Purification and characterization of a novel laccase from the edible mushroom Hericium coralloides[J]. The Journal of Microbiology, 2012, 50(1)：72-78.
[25] Peng CC, Chen KC, Peng RY, et al. Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells[J]. Journal of Ethnopharmacology, 2007, 109(1)：93-103.
[26] Chen NH, Zhong JJ. P53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells[J]. Phytomedicine, 2011, 18(8-9)：719-725.
[27] Tsai WC, Rao YK, Lin SS, et al. Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20(20)：6145-6148.
[28] Chiang PC, Lin SC, Pan SL, et al. Antroquinol displays anticancer potential against hman hepatocellular carcinoma cells：a crucial role of AMPK and mTOR pathways[J]. Biochem Pharmacol, 2010, 79(2)：162-171.
[29] Kumar S, Chu FH, Hsieh HW, et al. Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation[J]. Journal of Ethnopharmacology, 2011, 36(1)：168-177.
[30] Chun YC, Cheng CP, Lu PH, et al. Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells[J]. Journal of Nutritional Biochemistry, 2012, 23(8)：900-907.
[31] Kim MY, Seguin P, Ann JK, et al. Phenolic compound concentration and antioxidant activities of edible and medicinal mushrooms from Korea[J]. J Agric Food Chem, 2008, 56(16)：7265-7270.
[32] Ali NAA, Jansen R, Pilgrim H, et al. Hispolon, a yellow pigment from Inonotus ispidus[J]. Phytochemistry, 1996, 41(3)：927-929.
[33] Chen W, He FY, Li YQ, et al. The apoptosis effect of hispolon from Phellinus linteus(Berkeley & Curtis)Teng on humanepidermoid KB cells[J]. J Ethnopharmacol, 2006, 105(1-2)：280-285.
[34] Mo S, Wang S, Zhou G, et al. Phelligridins C-F：cytotoxic pyrano[4, 3-c][2]benzopyran- 1, 6-dione and furo[3, 2-c]pyran-4-one derivatives from the fungus Phellinus igniarius[J]. J Nat Prod, 2004, 67(5)：823-828.
[35] Chen W, Zhao Z, Li L, et al. Hispolon induces apoptosis in human gastric cancer cells through a ROS-mediated mitochondrial pathway[J]. Free Rad Biol Med, 2008, 45(1)：60-72.
[36] Lu TL, Huang GJ, Lu TJ, et al. Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells[J]. Food ChemToxicol, 2009, 47(8)：2013-2021.
[37] Akiyama H, Endo M, Matsui T, et al. Agaritine from Agaricus blazei Murrill induces apoptosis in the leukemic cell line U937[J]. Biochimica et Biophysica Acta, 2011, 1810(5)：519-525.
[38] Grob CS, Danforth AL, Chopra GS, et al. Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer[J]. Arch Gen Psychiatry, 2011, 68(1)：71-78.
[39] Jeong JW, Jin CY, Cheol P, et al. Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells[J]. Toxicology in Vitro, 2011, 25(4)：817-824.
[40] Zhao YY, Shen X, Chao X, et al. Ergosta-4, 6, 8(14), 22-tetraen-3-one induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[J]. BBA-Gen Subjects, 2011, 1810(4)：384-390.
[41] Yeh CT, Huang WC, Rao YK, et al. A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells[J]. Carcinogenesis, 2013, 34(12)：2918-2928.