A Review on Correlation Between Long Non-coding RNAs and Cancer as well as Stem Cells

doi:10.13560/j.cnki.biotech.bull.1985.2015.07.004

Abstract

Abstract: The human genome contains more than 20 000 protein-coding genes, only approximately 2% of the total genes, while over 90% of the transcripts are long non-coding RNAs(lncRNAs). lncRNAs are transcripts commonly distributed in genomes of most mammals, with length of 200 to 100 000 nt, but not possessing function of encoding proteins. Studies have shown that lncRNAs were abnormally expressed in numerous types of cancers, playing a potential oncogenic or suppressor role in tumorigenesis. Meanwhile, lncRNAs have been found to be critical regulators of various biological processes, and they were inseparable with the occurrence and development of tumors. Besides, lncRNAs play a vital role in maintaining pluripotency and regulating the gene expression, self-regeneration and differentiation in stem cells, and they are becoming the new hot spot in cancer researches after microRNA. In this review, we summarize the functions and underlying mechanisms of lncRNAs in cancer and in stem cells biology, which aims to provide new ideas about diagnosis, treatment, and prognosis of the tumor.

Key words: long non-coding RNAs, stem cells, cancer, oncogenic, suppressor, regulate

Wan Bo, Liao Shiqi, Yuan Hongxia, Ma Meilan, Zhu Jian, Zeng Jiayu. A Review on Correlation Between Long Non-coding RNAs and Cancer as well as Stem Cells[J]. Biotechnology Bulletin, 2015, 31(7): 33-39.

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