Research Progress on Drosophila Intestinal Stem Cells and Intestinal Microflora

doi:10.13560/j.cnki.biotech.bull.1985.2020-0875

Abstract

Abstract:

There are strong immune system,stem cells and micro ecosystem in the intestine of animals. The intestinal microflora plays an important role in maintaining the normal intestinal epithelium and immune function. Under normal conditions,the intestinal microflora of a host is in a state of micro-ecology equilibrium,and its symbiotic relationship is maintained. The change of intestinal microflora can cause metabolic diseases by affecting intestinal epithelial cells,and even change the behavior pattern of the host. The physiological structure,the mechanism of stem cell proliferation and differentiation,and the microhabitat of Drosophila’s gut are highly conserved with mammals. However,the structure of Drosophila intestinal microflora is far less complex than that of mammals. Therefore,Drosophila is an ideal model for studying the interaction between host and symbiotic bacteria. This paper will introduce and discuss the mechanism of the growth and differentiation of the symbiotic bacteria and stem cells in Drosophila’s gut,which is of great scientific significance to reveal the pathogenesis of human gut related diseases.

Key words: intestinal stem cells, proliferation and differentiation, intestinal microbiota

JIN Qiu-xia, WANG Si-hong, JIN Li-hua. Research Progress on Drosophila Intestinal Stem Cells and Intestinal Microflora[J]. Biotechnology Bulletin, 2021, 37(4): 245-250.

Figures/Tables 1

References 55

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