Research Progress on a Long Non-coding RNA MALAT1

doi:10.13560/j.cnki.biotech.bull.1985.2016.01.005

Abstract

Abstract: Long non-coding RNAs(lncRNAs)are the ones with transcripts that are longer than 200 nt. They do not encode proteins, but regulate the expression levels of the gene as a RNA molecular at transcriptional, post-transcriptional and epigenetic modification. Metastasis-associated lung adenocarcinoma transcript 1(MALAT1)was firstly discovered in non-small cell lung cancer, and has caused the concerns from scholars. MALAT1 located on chromosome 11q13.1 and was highly conserved. In recent years, studies have shown that MALAT1 specifically recruited SR protein family members, was involved in epigenetic regulation and cell cycle regulation. MALAT1, which is highly expressed in many human tumors, promotes tumor proliferation, invasion and metastasis. In addition, recently it is found that MALAT1 plays an important role in angiogenesis. This article systematically reviewed the characteristics and mechanism of MALAT1, as well as its biological function in tumor and vascular systems.

Key words: lncRNA, MALAT1, mechanism, tumor, angiogenesis

SONG Tie-feng, YUAN Ying, WANG Hui-qin, ZHUANG Chun-yu, WANG Nan, ZHANG Tong-cun. Research Progress on a Long Non-coding RNA MALAT1[J]. Biotechnology Bulletin, 2016, 32(1): 20-28.

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