Research Advances on the Structure,Function and Regulation of Defensins Gene Family in Plants

doi:10.13560/j.cnki.biotech.bull.1985.2017-0457

Abstract

Abstract: As the most ancient antimicrobial peptides（AMP）,plant defensins are small cysteine-rich proteins of 45-54 amino acids and a cysteine-stabilized αβ motif that are closely related to insect and mammalian defensins. Most plant defensins are synthesized as precursors with a signal peptide sequence and are secreted to extracellular space. Plant defensins play an important role in the regulation of host immune by not only inhibiting a range of bacteria and fungi from plants and human and also killing some tumor cells and protozoon. Plant defensins are widely existing in flowers,stems,leaves,fruits,roots and seeds of plants,and have the functions of anti-bacteria,anti-tumor,inhibiting enzyme activity,making ion blockers and increasing tolerance,thus can be used as novel fungicides or antibiotics-type medicine. With the appearance of drug-resistant strains resulted from using chemical antibiotics,the study of plant defensins becomes extremely important,especially because of their potent antifungal activity,they have huge potential for engineering disease resistance in crops. This paper reviewed progresses on the discovery,structural characteristics,classifications,exogenous expression,functions and mechanism of defensins in plants. It will help to elucidate the molecular bases of their function in plants more in-depth and comprehensive in future.

Key words: plant defensins, function, research advances, regulation

GUAN Li-li, CUI Qi, LI Sheng-zhao, DONG Cheng, LI Hai-long, PENG Jian-hao, LI Xiao-kun. Research Advances on the Structure,Function and Regulation of Defensins Gene Family in Plants[J]. Biotechnology Bulletin, 2018, 34(1): 33-39.

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