Research Progress on the Transformation of Magnetotactic Bacteria and Magnetosome Functionalization

doi:10.13560/j.cnki.biotech.bull.1985.2018-0269

Abstract

Abstract: Magnetotactic bacteria（MTB）are gram-negative bacteria that can move along magnetic field Lines under the action of an external magnetic field. The bacterial magnetosomes（BMs）in the bacteria are synthesized by MTB through biomineralization. BMs are arranged in chains within MTB and consist of outer membranes and internal magnetite crystals. BMs have the characteristics of uniform size,single magnetic domain,Large specific surface area,good biocompatibility,superparamagnetism and so on,and thus are widely used in the medical field. At present,MTB-based transformation methods are relatively few. And they are mainly biased to further transform the MTB by changing the morphology and composition of BMs. The functional strategies of BMs are relatively more and are mainly categorized into chemical and biological modification. This paper summarizes the basic features and screening techniques of MTB and BMs,focusing on the MTB transformation methods and the BMs functionalization strategies. Finally,the significance and existing problems of MTB transformation and BMs functionalization in practical applications are discussed,aiming at further promoting the practical application of MTB and BMs.

Key words: magnetotactic bacteria, transformation, magnetosomes, functionalization

ZHOU Zi-qi, LI Shu-ting, TIAN Jie-sheng, HE Wan-chong, XU Wen-tao. Research Progress on the Transformation of Magnetotactic Bacteria and Magnetosome Functionalization[J]. Biotechnology Bulletin, 2019, 35(4): 139-150.

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