Research Advance on PPARα Gene in Livestock and Poultry

doi:10.13560/j.cnki.biotech.bull.1985.2018-0504

Abstract

Abstract: The peroxisome proliferator activator receptor（PPARs）is the ligand activator receptor in the nuclear hormone receptor family,and controls the metabolic process in many cells. As an important member of the peroxisome proliferator activated receptor family,PPARα is a key hub for regulating body lipid metabolism,and plays a critical role in regulating lipid metabolism in the liver of livestock and poultry. PPARα genes are composed of 4 structural domains and are mostly expressed in the liver and adipose tissue of body. PPARα as a nuclear receptor is activated by binding exogenous and endogenous specific ligands,then binds to the target gene to exert a regulatory role in the liver lipid metabolism of body. In this paper we respectively review the structure characteristics of PPARα and its expression pattern,the regulation mechanism of PPARα gene on lipid metabolism in liver,and the research progress of PPARα in livestock and poultry at present stage,aiming at raising awareness of PPARα regulation in lipid metabolism and providing theoretical supports for studying mechanism of lipid metabolism in the livers of livestock and poultry and the treatment of related diseases.

Key words: PPARα, gene;, nuclear receptor, liver, lipid metabolism

WANG Zhao-yang, LAN Li-ming, BAI Ding-ping, ZHANG Fu-jun, LI Ang. Research Advance on PPARα Gene in Livestock and Poultry[J]. Biotechnology Bulletin, 2018, 34(12): 32-40.

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