Research Advances on the Influence of Intestinal Microorganism on the Immune Effect of Vaccine

doi:10.13560/j.cnki.biotech.bull.1985.2021-0162

Abstract

Abstract:

In the early stage of human life,the intestinal tract has been exposed to bacterial environment. Normal intestinal microbiome can maintain the homeostasis of intestinal environment by forming microbial barrier,secreting secondary metabolites and regulating host immunity. The vaccine is a kind of drug that plays a role through the host immune response. There are few reports on the relationship between vaccines and intestinal microbiome. In recent years,it has been found that intestinal microbiome has a vital impact on vaccine preparations. This paper reviews the reports on the interactions between intestinal microbiome and vaccines,aiming to provide theoretical basis and guidance for vaccine research and development.

Key words: intestinal microbiome, vaccine, host immunity

CHEN Si-qian, WU Bian, LIU Chen-jian, LI Xiao-ran. Research Advances on the Influence of Intestinal Microorganism on the Immune Effect of Vaccine[J]. Biotechnology Bulletin, 2021, 37(12): 220-226.

Figures/Tables 2

References 41

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