Biotechnology Bulletin ›› 2021, Vol. 37 ›› Issue (12): 220-226.doi: 10.13560/j.cnki.biotech.bull.1985.2021-0162

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Research Advances on the Influence of Intestinal Microorganism on the Immune Effect of Vaccine

CHEN Si-qian1(), WU Bian2, LIU Chen-jian1, LI Xiao-ran1()   

  1. 1. Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500
    2. The First People’s Hospital of Yunnan Province,the Affiliated Hospital of Kunming University of Science and Technology,Kunming 650032
  • Received:2021-02-06 Online:2021-12-26 Published:2022-01-19
  • Contact: LI Xiao-ran E-mail:13710537583@sina.cn;LiXR@kust.edu.cn

Abstract:

In the early stage of human life,the intestinal tract has been exposed to bacterial environment. Normal intestinal microbiome can maintain the homeostasis of intestinal environment by forming microbial barrier,secreting secondary metabolites and regulating host immunity. The vaccine is a kind of drug that plays a role through the host immune response. There are few reports on the relationship between vaccines and intestinal microbiome. In recent years,it has been found that intestinal microbiome has a vital impact on vaccine preparations. This paper reviews the reports on the interactions between intestinal microbiome and vaccines,aiming to provide theoretical basis and guidance for vaccine research and development.

Key words: intestinal microbiome, vaccine, host immunity