Advances on the Role of C-type Natriuretic Peptide in Regulating Animal Reproduction Processes

Abstract

Abstract: C-type natriuretic peptide(CNP), a member of the natriuretic peptide family of structurally related peptides, is a autocrine /paracrine growth factor with important roles in cardiovascular homeostasis, regulation of cell proliferation and skeletal development ； moreover,CNP also plays a key role in modulating animal reproductive processes. Notably, recent studies have revealed that CNP acts as a regulator toinhibit meiotic resumption in mouse oocytes in vivo ； additionally, CNP can enhances superovulation response by the stimulation of folliculardevelopment prior to gonadotropins treatment. In light of the findings above, CNP may be of special importance in the promotion of oocytedevelopment in vitro as one meiotic inhibitor, as well as the improvement of superovulation efficiency in domestic animals. Hence, this paperreviewed the structure of CNP, its role as one of functional molecules that modulate reproductive processes in animals and its potencial value.

Key words: C-type natriuretic peptide , Animal reproduction , Role

Jia Zhenwei, Zhang Jiaxin, An Lei, Wu Zhonghong, Tian Jianhui,. Advances on the Role of C-type Natriuretic Peptide in Regulating Animal Reproduction Processes[J]. Biotechnology Bulletin, 2013, 0(1): 36-40.

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