Research Progress on Bacterial Quorum Quenching Enzymes

doi:10.13560/j.cnki.biotech.bull.1985.2015.10.011

Abstract

Abstract: Quorum sensing（QS）is a phenomenon of intercellular communication of bacteria via signal molecules. Bacteria secrete the specific signal molecules and respond to them, and bacterial cells enable the expression of specific genes, especially disease-causing genes while the signal molecules accumulate to a threshold concentration. This provides a new thought to prevent plants and animals from bacterial pathogenicity. Quorum quenching（QQ）based on QS system is a schema to decompose the signal molecules beyond the threshold concentration, and therefore represses the expression of specific virulence gene, so finally the prevention and control of diseases are achieved. The enzymes of QQ have been explored the most and also proved to be the most effective ways of quenching. To date, many QQ enzymes have been isolated successfully. Here we review progress on QQ enzymes with aspects of their type, property, catalytic mechanism, and physiologic function.

Key words: quorum sensing, quorum quenching, molecule quenching enzyme, acyl homoserine acylase, acyl homoserine lactonase

Xing Qifan, Liu Pengfu, Shi Jiping, Sun Yumei. Research Progress on Bacterial Quorum Quenching Enzymes[J]. Biotechnology Bulletin, 2015, 31(10): 48-55.

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