Research Progress on Bacteriocins and Their Potential New Applications

doi:10.13560/j.cnki.biotech.bull.1985.2018-0354

Abstract

Abstract:

Bacteriocins are antimicrobial peptides synthesized in microbial ribosomes and are generally used as food preservatives. In recent years,scientists have selected a small number of bacteriocins to conduct in-depth study,opened up new research fields for bacteriocins,and extended their application area. With the rapid development of genetics and nanotechnology,bacteriocins are likely to be developed into the next generation of antibiotics,novel carrier molecules,and drugs for the treatment of tumors. Concurrently,scientists have discovered that some bacteriocins have the ability to regulate quorum sensing,this finding suggests that bacteriocins may be applied in new areas. At present,the bacteriocins produced by Gram-negative bacteria are mainly utilized for the study of translation and modification of bacteriocins,while the bacteriocins produced by Gram-positive bacteria（mainly lactic acid bacteria）are mainly for the study of bacteriocin application. Currently,the application of bacteriocins is expanding from the food field to human health. This review focuses on the function of bacteriocins and their effects,and describes their application from the food field to human health in detail,indicating the importance of bacteriocin.to further study bacteriocin laid the foundation for food antisepsis,human disease prevention and biological control.

Key words: bacteriocins, antibacterial activity, signal molecules, quorum sensing

MAO Wen, TIAN Lu, GONG Guo-li. Research Progress on Bacteriocins and Their Potential New Applications[J]. Biotechnology Bulletin, 2018, 34(10): 35-40.

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