Research Progress on Peptidoglycan Recognition Proteins in Fish

doi:10.13560/j.cnki.biotech.bull.1985.2018-0218

Abstract

Abstract: Peptidoglycan recognition proteins（PGRPs）are a family of highly-conserved pattern recognition receptors（PRRs）,they may recognize peptidoglycans,an essential component of bacterial cell wall,consequently activate and regulate innate immunes of a body. At present there are 23 reported fish PGRPs,and they were classified into three groups based on the length of the amino acid sequence,named short-PGRPs,intermediate-PGRPs and long-PGRPs. Its C-terminal PGRP domain is highly conserved although fish PGRPs have some differences in protein size,domain organization and subcellular localization. Fish PGRPs widely express in different tissues,its expression levels display notable changes in various immune tissues under the stimulation of different bacteria,thus we speculate that fish PGRPs are involved in the immune response. In addition,fish PGRPs also play a vital role in the physiological process and innate immune regulation of embryonic development. Currently,researches on the functions of fish PGRPs mainly focus on pathogen recognition,amidase activity,bactericidal ability and antimicrobial activity,as well as immune regulatory mechanisms;however,researches on the mechanisms of fish PGRPs remain swallow,and needs further deep researches. This paper reviews the structure,express and function of fish PGRPs,aiming at providing for further studying the function and application for PGRPs in fish.

Key words: fish, PGRP, bacteria, innate immunity

XIA Hong-li, CHENG Jun, YU Da-peng, CHEN Wen-jie, LU Yi-shan. Research Progress on Peptidoglycan Recognition Proteins in Fish[J]. Biotechnology Bulletin, 2018, 34(8): 58-66.

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