Biotechnology Bulletin ›› 2019, Vol. 35 ›› Issue (6): 164-171.doi: 10.13560/j.cnki.biotech.bull.1985.2019-0070

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Current Status and Progress on Prokaryotic Transcriptome Study

LIU Meng-yuan, LENG Yan, ZHAI Li-xiang, HE LI-fang, LI Shi-weng   

  1. School of Chemical and Biological Engineering,Lanzhou Jiaotong University,Lanzhou 730070
  • Received:2019-01-16 Online:2019-06-26 Published:2019-07-08

Abstract: The breakthrough of transcriptional technology in studying prokaryotes transcriptome has shown its unique advantage in revealing the molecular mechanism of prokaryotes’ life process. The transcriptome study of prokaryotes began with pathogenic bacteria,and recently the transcriptome analysis of the degradation mechanism of pollutants by prokaryotes has become a research focus. The metabolic mechanism,mechanism of action and transcription-related genes of degrading bacteria were further explored through multi-histological integration analysis. In this paper,the status and progress of the study on prokaryotic transcriptome are reviewed,i.e.,the degradation bacteria and their transcriptome characteristics in response to heavy metals,aromatic compounds,petroleum hydrocarbons and other organic pollutants are introduced. The transcriptome study of pathogenic bacteria is also focused,including human,animal and plant pathogenic bacteria species,nature,and transcriptome characteristics. The future development and application of transcriptome research in prokaryotes are also prospected. It aims to lay an important theoretical foundation for prokaryotes in environmental pollution control as well as prevention and control of human and animal and plant diseases caused by pathogenic bacteria.

Key words: prokaryotes, transcriptome, degradation bacteria, pathogenic bacteria