The Key Roles of Mediator Complex in Plant Responses to Abiotic Stress

doi:10.13560/j.cnki.biotech.bull.1985.2023-0847

Abstract

Abstract:

Mediator complex, as an essential coactivator in the eukaryotic transcription machinery, plays a crucial role in bridging RNA polymerase II and various transcription factors to regulate gene transcription. When plants encounter various abiotic stresses, the mediator complex integrates stress signals and activates or suppresses the expressions of target genes, thereby helping plants to adapt to environmental stress. This article summarizes the discovery of the mediator complex, and different functions of plant mediator complex under drought, salt, and extreme temperature conditions. It also discusses future research directions of the mediator complex to gain a deeper understanding of its role in regulating responses to abiotic stress.

Key words: mediator complex, plant, transcriptional regulation, abiotic stress

XU Rui, ZHU Ying-fang. The Key Roles of Mediator Complex in Plant Responses to Abiotic Stress[J]. Biotechnology Bulletin, 2023, 39(11): 54-60.

Figures/Tables 2

References 51

[1]	Liu Y, Ranish JA, Aebersold R, et al. Yeast nuclear extract contains two major forms of RNA polymerase II mediator complexes[J]. J Biol Chem, 2001, 276(10): 7169-7175. pmid: 11383511
[2]	Kornberg RD. Mediator and the mechanism of transcriptional activation[J]. Trends Biochem Sci, 2005, 30(5): 235-239. doi: 10.1016/j.tibs.2005.03.011 pmid: 15896740
[3]	Schilbach S, Hantsche M, Tegunov D, et al. Structures of transcription pre-initiation complex with TFIIH and Mediator[J]. Nature, 2017, 551(7679): 204-209. doi: 10.1038/nature24282 URL
[4]	Chong L, Shi XN, Zhu YF. Signal integration by cyclin-dependent kinase 8(CDK8)module and other mediator subunits in biotic and abiotic stress responses[J]. Int J Mol Sci, 2020, 22(1): 354. doi: 10.3390/ijms22010354 URL
[5]	Zhai QZ, Li CY. The plant Mediator complex and its role in jasmonate signaling[J]. J Exp Bot, 2019, 70(13): 3415-3424. doi: 10.1093/jxb/erz233 pmid: 31089685
[6]	Bäckström S, Elfving N, Nilsson R, et al. Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit[J]. Mol Cell, 2007, 26(5): 717-729. doi: 10.1016/j.molcel.2007.05.007 pmid: 17560376
[7]	Buendía-Monreal M, Gillmor CS. Mediator: a key regulator of plant development[J]. Dev Biol, 2016, 419(1): 7-18. doi: S0012-1606(16)30103-8 pmid: 27287881
[8]	An CF, Mou ZL. The function of the Mediator complex in plant immunity[J]. Plant Signal Behav, 2013, 8(3): e23182. doi: 10.4161/psb.23182 URL
[9]	Dolan WL, Chapple C. Conservation and divergence of mediator structure and function: insights from plants[J]. Plant Cell Physiol, 2017, 58(1): 4-21. doi: 10.1093/pcp/pcw176 pmid: 28173572
[10]	Chen JL, Yang S, Fan BF, et al. The mediator complex: a central coordinator of plant adaptive responses to environmental stresses[J]. Int J Mol Sci, 2022, 23(11): 6170. doi: 10.3390/ijms23116170 URL
[11]	Hasan ASMM, Vander Schoor JK, Hecht V, et al. The CYCLIN-DEPENDENT KINASE module of the mediator complex promotes flowering and reproductive development in pea[J]. Plant Physiol, 2020, 182(3): 1375-1386. doi: 10.1104/pp.19.01173 pmid: 31964799
[12]	Liu AL, Xiao ZX, Li MW, et al. Transcriptomic reprogramming in soybean seedlings under salt stress[J]. Plant Cell Environ, 2019, 42(1): 98-114. doi: 10.1111/pce.13186
[13]	Son S, Park SR. Plant translational reprogramming for stress resilience[J]. Front Plant Sci, 2023, 14: 1151587. doi: 10.3389/fpls.2023.1151587 URL
[14]	Weil PA, Luse DS, Segall J, et al. Selective and accurate initiation of transcription at the Ad2 major late promotor in a soluble system dependent on purified RNA polymerase II and DNA[J]. Cell, 1979, 18(2): 469-484. pmid: 498279
[15]	Gill G, Ptashne M. Negative effect of the transcriptional activator GAL4[J]. Nature, 1988, 334(6184): 721-724. doi: 10.1038/334721a0
[16]	Kelleher RJ 3rd, Flanagan PM, Kornberg RD. A novel mediator between activator proteins and the RNA polymerase II transcription apparatus[J]. Cell, 1990, 61(7): 1209-1215. doi: 10.1016/0092-8674(90)90685-8 pmid: 2163759
[17]	Meisterernst M, Roy AL, Lieu HM, et al. Activation of class II gene transcription by regulatory factors is potentiated by a novel activity[J]. Cell, 1991, 66(5): 981-993. pmid: 1889091
[18]	Flanagan PM, Kelleher RJ, Sayre MH, et al. A mediator required for activation of RNA polymerase II transcription in vitro[J]. Nature, 1991, 350(6317): 436-438. doi: 10.1038/350436a0
[19]	Kim YJ, Björklund S, Li Y, et al. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II[J]. Cell, 1994, 77(4): 599-608. doi: 10.1016/0092-8674(94)90221-6 pmid: 8187178
[20]	Bourbon HM, Aguilera A, Ansari AZ, et al. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II[J]. Mol Cell, 2004, 14(5): 553-557. doi: 10.1016/j.molcel.2004.05.011 URL
[21]	Soutourina J. Transcription regulation by the mediator complex[J]. Nat Rev Mol Cell Biol, 2018, 19(4): 262-274. doi: 10.1038/nrm.2017.115 URL
[22]	Huang CQ, Xu R, Liégeois S, et al. Differential requirements for mediator complex subunits in Drosophila melanogaster host defense against fungal and bacterial pathogens[J]. Front Immunol, 2021, 11: 478958. doi: 10.3389/fimmu.2020.478958 URL
[23]	Mathur S, Vyas S, Kapoor S, et al. The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot(Arabidopsis)and a monocot(rice)during reproduction and abiotic stress[J]. Plant Physiol, 2011, 157(4): 1609-1627. doi: 10.1104/pp.111.188300 URL
[24]	Chen K, Li GJ, Bressan RA, et al. Abscisic acid dynamics, signaling, and functions in plants[J]. J Integr Plant Biol, 2020, 62(1): 25-54. doi: 10.1111/jipb.12899
[25]	Zeevaart JA. Changes in the levels of abscisic acid and its metabolites in excised leaf blades of Xanthium strumarium during and after water stress[J]. Plant Physiol, 1980, 66(4): 672-678. doi: 10.1104/pp.66.4.672 pmid: 16661500
[26]	Chen R, Jiang HL, Li L, et al. The Arabidopsis mediator subunit MED25 differentially regulates jasmonate and abscisic acid signaling through interacting with the MYC2 and ABI5 transcription factors[J]. Plant Cell, 2012, 24(7): 2898-2916. doi: 10.1105/tpc.112.098277 URL
[27]	Guo PC, Chong L, Wu FM, et al. Mediator tail module subunits MED16 and MED25 differentially regulate abscisic acid signaling in Arabidopsis[J]. J Integr Plant Biol, 2021, 63(4): 802-815. doi: 10.1111/jipb.v63.4 URL
[28]	Li XH, Yang R, Gong YF, et al. The Arabidopsis mediator complex subunit MED19a is involved in ABI5-mediated ABA responses[J]. J Plant Biol, 2018, 61(2): 97-110. doi: 10.1007/s12374-017-0277-7
[29]	Lai ZB, Schluttenhofer CM, Bhide K, et al. MED18 interaction with distinct transcription factors regulates multiple plant functions[J]. Nat Commun, 2014, 5: 3064. doi: 10.1038/ncomms4064 pmid: 24451981
[30]	Zhu YF, Huang PC, Guo PC, et al. CDK8 is associated with RAP2.6 and SnRK2.6 and positively modulates abscisic acid signaling and drought response in Arabidopsis[J]. New Phytol, 2020, 228(5): 1573-1590. doi: 10.1111/nph.v228.5 URL
[31]	Wang YF, Hou YX, Qiu JH, et al. Abscisic acid promotes jasmonic acid biosynthesis via a ‘SAPK10-bZIP72-AOC’ pathway to synergistically inhibit seed germination in rice(Oryza sativa)[J]. New Phytol, 2020, 228(4): 1336-1353. doi: 10.1111/nph.v228.4 URL
[32]	Ju L, Jing YX, Shi PT, et al. JAZ proteins modulate seed germination through interaction with ABI5 in bread wheat and Arabidopsis[J]. New Phytol, 2019, 223(1): 246-260. doi: 10.1111/nph.2019.223.issue-1 URL
[33]	McGrath KC, Dombrecht B, Manners JM, et al. Repressor- and activator-type ethylene response factors functioning in jasmonate signaling and disease resistance identified via a genome-wide screen of Arabidopsis transcription factor gene expression[J]. Plant Physiol, 2005, 139(2): 949-959. doi: 10.1104/pp.105.068544 pmid: 16183832
[34]	Kazan K. The multitalented MEDIATOR25[J]. Front Plant Sci, 2017, 8: 999. doi: 10.3389/fpls.2017.00999 pmid: 28659948
[35]	Zhang H, Zhao Y, Zhu JK. Thriving under stress: how plants balance growth and the stress response[J]. Dev Cell, 2020, 55(5): 529-543. doi: 10.1016/j.devcel.2020.10.012 pmid: 33290694
[36]	Gupta A, Rico-Medina A, Caño-Delgado AI. The physiology of plant responses to drought[J]. Science, 2020, 368(6488): 266-269. doi: 10.1126/science.aaz7614 pmid: 32299946
[37]	Elfving N, Davoine C, Benlloch R, et al. The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development[J]. Proc Natl Acad Sci USA, 2011, 108(20): 8245-8250. doi: 10.1073/pnas.1002981108 pmid: 21536906
[38]	Lin LH, Du MM, Li SY, et al. Mediator complex subunit MED25 physically interacts with DST to regulate spikelet number in rice[J]. J Integr Plant Biol, 2022, 64(4): 871-883. doi: 10.1111/jipb.13238
[39]	Zhu YF, Schluttenhoffer CM, Wang PC, et al. CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and-independent functions in Arabidopsis[J]. Plant Cell, 2014, 26(10): 4149-4170. doi: 10.1105/tpc.114.128611 URL
[40]	Lee M, Dominguez-Ferreras A, Kaliyadasa E, et al. Mediator subunits MED16, MED14, and MED2 are required for activation of ABRE-dependent transcription in Arabidopsis[J]. Front Plant Sci, 2021, 12: 649720. doi: 10.3389/fpls.2021.649720 URL
[41]	Zhu YF, Wang B, Tang K, et al. An Arabidopsis Nucleoporin NUP85 modulates plant responses to ABA and salt stress[J]. PLoS Genet, 2017, 13(12): e1007124. doi: 10.1371/journal.pgen.1007124 URL
[42]	Crawford T, Karamat F, Lehotai N, et al. Specific functions for mediator complex subunits from different modules in the transcriptional response of Arabidopsis thaliana to abiotic stress[J]. Sci Rep, 2020, 10(1): 5073. doi: 10.1038/s41598-020-61758-w pmid: 32193425
[43]	Warren G, McKown R, Marin AL, et al. Isolation of mutations affecting the development of freezing tolerance in Arabidopsis thaliana(L.) Heynh[J]. Plant Physiol, 1996, 111(4): 1011-1019. doi: 10.1104/pp.111.4.1011 pmid: 8756493
[44]	Knight H, Veale EL, Warren GJ, et al. The sfr6 mutation in Arabidopsis suppresses low-temperature induction of genes dependent on the CRT/DRE sequence motif[J]. Plant Cell, 1999, 11(5): 875-886. doi: 10.1105/tpc.11.5.875 pmid: 10330472
[45]	Knight H, Mugford SG, Ulker B, et al. Identification of SFR6, a key component in cold acclimation acting post-translationally on CBF function[J]. Plant J, 2009, 58(1): 97-108. doi: 10.1111/tpj.2009.58.issue-1 URL
[46]	Hemsley PA, Hurst CH, Kaliyadasa E, et al. The Arabidopsis mediator complex subunits MED16, MED14, and MED2 regulate mediator and RNA polymerase II recruitment to CBF-responsive cold-regulated genes[J]. Plant Cell, 2014, 26(1): 465-484. doi: 10.1105/tpc.113.117796 URL
[47]	Ohama N, Moo TL, Chua NH. Differential requirement of MED14/17 recruitment for activation of heat inducible genes[J]. New Phytol, 2021, 229(6): 3360-3376. doi: 10.1111/nph.17119 pmid: 33251584
[48]	魏荷, 李海朝, 练云, 等. 大豆中介体亚基基因鉴定及表达特性分析[J]. 大豆科学, 2016, 35(1): 31-38.
	Wei H, Li HC, Lian Y, et al. Identification and expression profiles of mediator subunit genes in soybean[J]. Soybean Sci, 2016, 35(1): 31-38.
[49]	王晶, 赵军, 宗娜. 玉米中介体亚基ZmMED7基因的克隆及表达分析[J]. 生物技术进展, 2016, 6(5): 328-335, 381. doi: 10.3969/j.issn.2095-2341.2016.05.04
	Wang J, Zhao J, Zong N. Cloning and expression analysis of maize mediator subunit gene ZmMED7[J]. Curr Biotechnol, 2016, 6(5): 328-335, 381.
[50]	Guo J, Wei L, Chen SS, et al. The CBP/p300 histone acetyltransferases function as plant-specific MEDIATOR subunits in Arabidopsis[J]. J Integr Plant Biol, 2021, 63(4): 755-771. doi: 10.1111/jipb.v63.4 URL
[51]	Liao CJ, Lai ZB, Lee SH, et al. Arabidopsis HOOKLESS1 regulates responses to pathogens and abscisic acid through interaction with MED18 and acetylation of WRKY33 and ABI5 chromatin[J]. Plant Cell, 2016, 28(7): 1662-1681.