Biological Functions and Regulatory Network of SLR1， a Negative Regulator of Gibberellin Signaling in Rice

doi:10.13560/j.cnki.biotech.bull.1985.2025-0643

Abstract

Abstract:

Gibberellins (GAs) are a class of important regulatory hormones in plants, widely involved in various life processes such as plant growth and development, and responses to stress. The regulation of GA biosynthesis and signaling pathways contributed to the first green revolution in crop breeding. SLR1 is the only DELLA protein in rice, serving as a key negative regulator in the GA signal transduction pathway that represses downstream GA signal transduction. SLR1 also participates in hormone pathways such as abscisic acid (ABA), jasmonic acid (JA), brassinosteroid (BR), and strigolactone (SL), acting as a "molecular bridge" for plant hormone crosstalk. However, the SLR1 protein lacks a typical DNA-binding domain, and there is currently no evidence indicating its ability to directly bind to DNA sequences. It mainly exerts its modulatory functions by interacting with other transcription factors to inhibit or activate the expressions of downstream genes. In addition, the expression and function of SLR1 itself are also subject to multiple regulations. At the transcriptional level, the SLR1 gene is negatively regulated by transcription factors such as OsYABBY4 and OsWRKY36; at the protein level, SLR1 undergoes modifications including ubiquitination, glycosylation, SUMOylation, and phosphorylation, as well as regulation of its own stability and activity through interactions with other proteins. SLR1 not only extensively regulates various growth and development processes but also participates responses to multiple biotic and abiotic stresses in rice, playing an important role throughout the entire growth cycle of rice. Recent research has revealed the great potential of SLR1 in breeding: regulating the protein abundance of SLR1 in rice and maintaining it at a moderate level is of great significance for improving rice tolerance to alkali and heat stress. This article mainly reviews the molecular structure and mechanism of action of SLR1, its crosstalk role in various plant hormone pathways, the protein modifications and regulations of SLR1 itself, as well as its specific biological functions. It aims to further explore SLR1-associated components and regulatory networks, providing references for rice molecular design breeding.

Key words: rice, SLR1 protein, gibberellin, hormone crosstalk, protein modification, regulatory network, biological function, abiotic stress

FEI Si-tian, HOU Ying-xiang, LI Lan, ZHANG Chao. Biological Functions and Regulatory Network of SLR1， a Negative Regulator of Gibberellin Signaling in Rice[J]. Biotechnology Bulletin, 2026, 42(1): 13-30.

Figures/Tables 7

References 103

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相关基因或蛋白 Related genes or proteins	相关通路 Related pathways	生物学功能 Biological function	参考文献 Reference
GID1， GID2	GA	介导SLR1的降解，调控GA信号途径 Mediate the degradation of SLR1 and regulate the GA signaling pathway	［19-33］
D14	GA， SL	促进SLR1的降解，调控水稻分蘖 Promote the degradation of SLR1 and regulate rice tillering	［28］
D53	SL，氮素信号	高氮条件下，抑制D14介导SLR1的降解，调控氮素利用 Under high-nitrogen conditions， inhibit D14-mediated degradation of SLR1 to regulate nitrogen utilization	［28］
PRC2， HDA702	GA	介导染色质沉默 Mediate chromatin silencing	［32］
EL1	GA	促进SLR1磷酸化，调控GA信号途径 Promote the phosphorylation of SLR1， regulate the GA signaling pathway	［38］
OsSPY	GA	激活SLR1的抑制活性 Activate the inhibitory activity of SLR1	［39-40］
OsYABBY4	GA	调控小穗发育 Regulate spikelet development	［41］
OsWRKY36	GA	抑制GA信号和调控植株 Inhibit GA signaling and regulate plant height	［42］
OsMYB91	GA， ABA	平衡水稻生长和非生物胁迫抗性 Balance rice growth and abiotic stress resistance	［43］
RTD1	GA	负调控SLR1蛋白的转录和蛋白水平 Negatively regulate the transcription and protein level of SLR1 protein	［44］
OsNPC6	GA	调控中胚轴伸长 Regulate mesocotyl elongation	［45］
CIPK31	GA	抑制SLR1蛋白降解 Inhibit the degradation of SLR1 protein	［46］
OsGAMYBL2	GA， BR	调控GA合成和BR信号 Regulate GA biosynthesis and BR signaling	［54］
OsJAZ8， OsJAZ9	JA	调控水稻生长发育与抗逆 Regulate rice growth and development as well as stress resistance	［56］
MYC2/3	JA	调控JA响应基因的表达 Regulate the expression of JA-responsive genes	［57］
SP8， P2， M	GA， JA	介导广谱抗病毒防御反应 Mediate broad-spectrum antiviral defense response	［57］
TAD1	ABA	抑制ABA信号 Inhibit ABA signaling	［59］
MOC1	GA	调控株高和分蘖 Regulate plant height and tillering	［60］
NGR5	GA	提高氮素利用、促进分蘖 Enhance nitrogen utilization and promote tillering	［61］
OsMADS23	GA， SL	抑制D14基因转录，促进分蘖 Suppress the transcription of the D14 gene and promote tillering	［62-63］
OsIDD2	GA	调控细胞增殖 Regulate cell proliferation	［64］
OsNAC29/31	GA	调控纤维素合成 Regulate cellulose synthesis	［65］
OsKNAT7	GA	调控次生细胞壁的合成 Regulate the synthesis of secondary cell walls	［66］
OsMYB103L	GA	调控纤维素生物和次生细胞壁合成 Regulate cellulose and secondary cell wall biosynthesis	［67］
OsNAC055	木质素合成途径	调控木质素合成 Regulate lignin biosynthesis	［68］
GAMYB	GA	调控水稻育性 Regulate rice fertility	［69-70］
UDT1， TDR	GA	提高绒毡层发育相关基因的表达，调控水稻的育性 Enhance the expressions of tapetum development-related genes and regulate rice fertility	［71］
OsMS188	GA	调控孢粉素生物合成，促进花粉壁的形成 Regulate sporopollenin biosynthesis and promote pollen wall formation	［72］
OSH1	GA	调控次生细胞壁合成 Regulate secondary cell wall biosynthesis	［73］
RID1	GA	调控营养生长向生殖生长的转变 Regulate the transition from vegetative growth to reproductive growth	［74］
GHD7	GA	调控抽穗期和植株形态 Regulate rice heading date and plant morphology	［75］
qSH1， OSH15， SNB	GA	调控木质素含量和落粒性 Regulate lignin biosynthesis and seed shattering	［76］
OsNAC120	GA， ABA	调控干旱胁迫响应 Regulate the response to drought stress	［77］
OsBURP3， OsSUS1	GA	调控干旱胁迫响应 Regulate the response to drought stress	［78］
OsPIL13/14	GA，光信号	调控黑暗或盐胁迫下的幼苗生长 Regulate seedling growth under darkness or salt stress	［79-80］
OsNF-YA3	GA， ABA	调控生长发育与渗透胁迫耐受性 Regulate growth and development as well as osmotic stress tolerance	［81］
IDD10， bZIP23	GA，氮素信号	调控氮素吸收和盐碱耐受性 Regulate nitrogen absorption and saline-alkali tolerance	［82］
OsGRF6	GA	调控水稻生长和耐寒性 Regulate rice growth and cold tolerance	［83］
OsNuCYP20-2	GA	促进SLR1的降解，促进细胞伸长 Promote the degradation of SLR1 and cell elongation	［84］
Sub1A	GA， ET， ABA	促进SLR1的积累，抑制GA信号 Promote the accumulation of SLR1 and inhibit GA signaling	［85-87］
GRF4	GA， BR	调节根系代谢和氮素利用 Regulate root metabolism and nitrogen utilization	［88］
OsWRKY71	GA	调控逆境下的根系发育 Regulate root development under stress conditions	［89］
OsSPL7， OsSPL14	GA	调控Xoo的抗性 Regulate resistance to Xanthomonasoryzae pv. oryzae （Xoo）	［90-91］
LPA1	GA	对水稻纹枯病rice sheath blight（ShB）的抗性 Resistance to rice sheath blight （ShB）	［92］

相关基因或蛋白 Related genes or proteins	相关通路 Related pathways	生物学功能 Biological function	参考文献 Reference
GID1， GID2	GA	介导SLR1的降解，调控GA信号途径 Mediate the degradation of SLR1 and regulate the GA signaling pathway	［19-33］
D14	GA， SL	促进SLR1的降解，调控水稻分蘖 Promote the degradation of SLR1 and regulate rice tillering	［28］
D53	SL，氮素信号	高氮条件下，抑制D14介导SLR1的降解，调控氮素利用 Under high-nitrogen conditions， inhibit D14-mediated degradation of SLR1 to regulate nitrogen utilization	［28］
PRC2， HDA702	GA	介导染色质沉默 Mediate chromatin silencing	［32］
EL1	GA	促进SLR1磷酸化，调控GA信号途径 Promote the phosphorylation of SLR1， regulate the GA signaling pathway	［38］
OsSPY	GA	激活SLR1的抑制活性 Activate the inhibitory activity of SLR1	［39-40］
OsYABBY4	GA	调控小穗发育 Regulate spikelet development	［41］
OsWRKY36	GA	抑制GA信号和调控植株 Inhibit GA signaling and regulate plant height	［42］
OsMYB91	GA， ABA	平衡水稻生长和非生物胁迫抗性 Balance rice growth and abiotic stress resistance	［43］
RTD1	GA	负调控SLR1蛋白的转录和蛋白水平 Negatively regulate the transcription and protein level of SLR1 protein	［44］
OsNPC6	GA	调控中胚轴伸长 Regulate mesocotyl elongation	［45］
CIPK31	GA	抑制SLR1蛋白降解 Inhibit the degradation of SLR1 protein	［46］
OsGAMYBL2	GA， BR	调控GA合成和BR信号 Regulate GA biosynthesis and BR signaling	［54］
OsJAZ8， OsJAZ9	JA	调控水稻生长发育与抗逆 Regulate rice growth and development as well as stress resistance	［56］
MYC2/3	JA	调控JA响应基因的表达 Regulate the expression of JA-responsive genes	［57］
SP8， P2， M	GA， JA	介导广谱抗病毒防御反应 Mediate broad-spectrum antiviral defense response	［57］
TAD1	ABA	抑制ABA信号 Inhibit ABA signaling	［59］
MOC1	GA	调控株高和分蘖 Regulate plant height and tillering	［60］
NGR5	GA	提高氮素利用、促进分蘖 Enhance nitrogen utilization and promote tillering	［61］
OsMADS23	GA， SL	抑制D14基因转录，促进分蘖 Suppress the transcription of the D14 gene and promote tillering	［62-63］
OsIDD2	GA	调控细胞增殖 Regulate cell proliferation	［64］
OsNAC29/31	GA	调控纤维素合成 Regulate cellulose synthesis	［65］
OsKNAT7	GA	调控次生细胞壁的合成 Regulate the synthesis of secondary cell walls	［66］
OsMYB103L	GA	调控纤维素生物和次生细胞壁合成 Regulate cellulose and secondary cell wall biosynthesis	［67］
OsNAC055	木质素合成途径	调控木质素合成 Regulate lignin biosynthesis	［68］
GAMYB	GA	调控水稻育性 Regulate rice fertility	［69-70］
UDT1， TDR	GA	提高绒毡层发育相关基因的表达，调控水稻的育性 Enhance the expressions of tapetum development-related genes and regulate rice fertility	［71］
OsMS188	GA	调控孢粉素生物合成，促进花粉壁的形成 Regulate sporopollenin biosynthesis and promote pollen wall formation	［72］
OSH1	GA	调控次生细胞壁合成 Regulate secondary cell wall biosynthesis	［73］
RID1	GA	调控营养生长向生殖生长的转变 Regulate the transition from vegetative growth to reproductive growth	［74］
GHD7	GA	调控抽穗期和植株形态 Regulate rice heading date and plant morphology	［75］
qSH1， OSH15， SNB	GA	调控木质素含量和落粒性 Regulate lignin biosynthesis and seed shattering	［76］
OsNAC120	GA， ABA	调控干旱胁迫响应 Regulate the response to drought stress	［77］
OsBURP3， OsSUS1	GA	调控干旱胁迫响应 Regulate the response to drought stress	［78］
OsPIL13/14	GA，光信号	调控黑暗或盐胁迫下的幼苗生长 Regulate seedling growth under darkness or salt stress	［79-80］
OsNF-YA3	GA， ABA	调控生长发育与渗透胁迫耐受性 Regulate growth and development as well as osmotic stress tolerance	［81］
IDD10， bZIP23	GA，氮素信号	调控氮素吸收和盐碱耐受性 Regulate nitrogen absorption and saline-alkali tolerance	［82］
OsGRF6	GA	调控水稻生长和耐寒性 Regulate rice growth and cold tolerance	［83］
OsNuCYP20-2	GA	促进SLR1的降解，促进细胞伸长 Promote the degradation of SLR1 and cell elongation	［84］
Sub1A	GA， ET， ABA	促进SLR1的积累，抑制GA信号 Promote the accumulation of SLR1 and inhibit GA signaling	［85-87］
GRF4	GA， BR	调节根系代谢和氮素利用 Regulate root metabolism and nitrogen utilization	［88］
OsWRKY71	GA	调控逆境下的根系发育 Regulate root development under stress conditions	［89］
OsSPL7， OsSPL14	GA	调控Xoo的抗性 Regulate resistance to Xanthomonasoryzae pv. oryzae （Xoo）	［90-91］
LPA1	GA	对水稻纹枯病rice sheath blight（ShB）的抗性 Resistance to rice sheath blight （ShB）	［92］