Research Progress on Functional Nucleic Acid Biosensors Mediated by DNA/Silver Nanoclusters

doi:10.13560/j.cnki.biotech.bull.1985.2019-0963

Abstract

Abstract: DNA/Silver nanocluster（DNA/Ag NCs）is a novel fluorescent nanomaterial produced by using DNA as a template and NaBH₄ and silver ions as reactants. In recent years,silver nanoclusters have become a hotspot in the design and applications of biological sensors due to their excellent photophysical properties,fine biocompatibility,low cost and low toxicity. The signal output methods in DNA/silver nanocluster-mediated biosensor are categorized,and the applications of DNA/Ag NCs in vivo imaging and bacteriostasis are also summarized. Finally,the shortcomings of DNA/Ag NCs-mediated biosensors and their future development trends are prospected.

Key words: fluorescence, silver nanoclusters, biosensors, functional nucleic acids

YANG Min, LI Shu-ting, YANG Wen-ping, LI Xiang-yang, XU Wen-tao. Research Progress on Functional Nucleic Acid Biosensors Mediated by DNA/Silver Nanoclusters[J]. Biotechnology Bulletin, 2020, 36(6): 245-254.

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