Biotechnology Bulletin ›› 2020, Vol. 36 ›› Issue (7): 1-14.doi: 10.13560/j.cnki.biotech.bull.1985.2020-0262

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Advances on the Molecular Action Mechanisms of Plant miRNA

ZHANG Cui-ju, MO Bei-xin, CHEN Xue-mei, CUI Jie   

  1. College of Life Sciences and Oceanography,Shenzhen University,Shenzhen 518037
  • Received:2020-03-12 Online:2020-07-26 Published:2020-07-28

Abstract: microRNAs(miRNAs)are a class of 20- to 24-nucleotide(nt)endogenous noncoding single-stranded RNAs widely exisitng in eukaryote. miRNAs in plants negatively regulate the expressions of target genes through mRNA cleavage or translation repression and play important roles in cell proliferation and differentiation,growth and development of an individual,and responses to environmental stresses. Since the first identification of plant miRNAs in 2002,research on miRNAs has become a hotspot in the field of plant molecular biology. Decades of research have elucidated the mechanisms of miRNA biogenesis and degradation and revealed the regulatory roles of miRNAs in numerous biological processes in plants. However,mechanisms underpinning the action of plant miRNAs are still not well understood,especially with respect to miRNA-mediated translation repression. This review summarizes both historical perspectives and the latest progress on the plant miRNAs-mediated mRNA cleavage and translation repression,discusses the influencing factors and relationship of two mechanisms,and suggests the research direction and thoughts in future,aiming at providing a theoretical basis for in-depth understanding of the mechanism of plant miRNA and promoting the basic research and practical application of miRNA.

Key words: miRNA, mRNA cleavage, translation repression, phasiRNA