Abstract:

Inflammatory bowel disease（IBD）,comprising ulcerative colitis（UC）and Crohn’s disease（CD）,is an idiopathic inflammatory disease most commonly affecting the ileum,rectum,and colon. It shows highly heterogeneous in terms of clinical manifestation,disease’s progression and therapeutic response. Currently,there is no consensus on the pathogenesis underlying IBD,while the treatment options are quite limited. Overactive inflammatory responses are leading to the damage of intestinal mucosal barrier and disorder of intestinal flora disturbance,which is caused by genetic factors,environmental factors,intestinal micro-ecology and host immunological imbalance. Revealing the complex interaction mechanism in the pathogenesis of IBD,excavating potential therapeutic targets,and developing effective intervention strategies cannot be achieved via mono-omics analysis. Thus,there is a need to apply multi-omics association analysis techniques in further elucidating the pathogenesis of IBD at multiple dimensions. In this review,we retrospect and analyze the application of multi-omics techniques in fields related to IBD research. Moreover,we discuss their potential in the fields of individualized diagnosis and treatment,early diagnosis,and IBD typing,which is aimed to lay a foundation in further investigation of IBD.

Key words: inflammatory bowel disease, muliti-omics association analysis, genomics, microbiome, diagnosis and treatment strategy