Research Advances in Strategies for Improving the Activity of Microbial-derived Alkaline Proteases

doi:10.13560/j.cnki.biotech.bull.1985.2020-1043

Abstract

Abstract:

Alkaline protease is an important protease widely used in industry. At present,the domestic high-end washing protease mainly depends on the import,one of the factors restricting the domestic high-end washing protease is that the enzyme activity is not high. In this paper,the strategies to improve the activity of alkaline protease in microorganisms were described from three aspects：strain modification,protein engineering,and regulation of the expression of alkaline protease by optimizing the promoter or signal peptide. Finally,how to improve the activity of alkaline protease from microorganism in the future is prospected.

Key words: alkaline protease, enzyme activity, strategies

YUAN Yuan, WANG Lei, SHI Ya-wei. Research Advances in Strategies for Improving the Activity of Microbial-derived Alkaline Proteases[J]. Biotechnology Bulletin, 2021, 37(5): 231-236.

Figures/Tables 1

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